Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Christian Doerig, Oliver Billker, David Pratt, Jane Endicott

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The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases caused by parasitic protists. Here, we present an overview of recent developments in this field, concentrating (i) on the benefits gained from the availability of genomic databases for a number of parasitic protozoa, (ii) on the emerging field of structure-aided design of inhibitors targeting protein kinases of parasitic protists, (iii) on the concept known as transmission-blockade, whereby kinases implicated in the development of the parasite in their arthropod vector might be targeted to interfere with disease transmission, and (iv) on the possibility of controlling parasitic diseases through the inhibition of host cell protein kinases that are required for the establishment of infection by the parasites.

Original languageEnglish
Pages (from-to)132-150
Number of pages19
JournalBBA Proteins and Proteomics
Issue number1-2
Publication statusPublished - 30 Dec 2005
Externally publishedYes


  • Development
  • Drug discovery
  • Entamoeba
  • Inhibitor
  • Malaria
  • Parasite
  • Plasmodium
  • Protein kinase
  • Theileria
  • Toxoplasma
  • Trypanosoma

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