Protein kinase C-beta 1 gene variants are not associated with autism in the Irish population

Mao S. Yang, Lynne Cochrane, Judith Conroy, Ziarih Hawi, Michael F Fitzgerald, Louise Gallagher, Michael Gill

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Some evidences indicate that protein kinase C-beta 1 (PRKCB1) gene may be a predisposition locus of autism. A recent study reported evidence of association between autism and two haplotypes made up of six noncoding single nucleotide polymorphisms in the PRKCB1. To attempt replication of their findings, we examined the same six single nucleotide polymorphisms of PRKCB1 in 171 Irish autism trios. The haploview program was used to calculate D′ as a measure of linkage disequilibrium. The transmission disequilibrium test for single nucleotide polymorphism markers and haplotypes was carried out using the TDTPHASE and PDTPHASE from the UNPHASED version 2.404 programs. Transmission disequilibrium test analysis showed no evidence of association for any of the six single nucleotide polymorphisms at the PRKCB1 that we studied, or any of their haplotypes. Our data do not support the finding that the PRKCB1 gene variants contribute risk for the development of autism.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalPsychiatric Genetics
Issue number1
Publication statusPublished - Feb 2007
Externally publishedYes


  • Autism
  • Genetic association
  • Protein kinase C-beta 1
  • Single nucleotide polymorphism
  • Transmission disequilibrium test

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