Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

D. E. Jackson, C. A. Mitchell, H. H. Salem

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalThrombosis and Haemostasis
Volume72
Issue number1
Publication statusPublished - 1994

Cite this

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title = "Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro",
abstract = "When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.",
author = "Jackson, {D. E.} and Mitchell, {C. A.} and Salem, {H. H.}",
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journal = "Thrombosis and Haemostasis",
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Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro. / Jackson, D. E.; Mitchell, C. A.; Salem, H. H.

In: Thrombosis and Haemostasis, Vol. 72, No. 1, 1994, p. 70-73.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

AU - Jackson, D. E.

AU - Mitchell, C. A.

AU - Salem, H. H.

PY - 1994

Y1 - 1994

N2 - When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.

AB - When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.

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M3 - Article

VL - 72

SP - 70

EP - 73

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

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