Protein C is responsible for the rapid inactivation of factor Va following blood clotting in vitro

D. E. Jackson, C. A. Mitchell, H. H. Salem

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When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - 1994

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