Protein and peptide delivery to lungs by using advanced targeted drug delivery

Dinesh Kumar Chellappan, Parteek Prasher, Vilashini Saravanan, Vanessa See Vern Yee, Wendy Chai Wen Chi, Jia Wei Wong, Joon Kang Wong, Jing Tong Wong, Wai Wan, Jestin Chellian, Nagashekhara Molugulu, Sakthivel Lakshmana Prabu, Rania Ibrahim, Thiviya Darmarajan, Mayuren Candasamy, Pankaj Kumar Singh, Vijay Mishra, Madhur D. Shastri, Flavia C. Zacconi, Amlan ChakrabortyMeenu Mehta, Piyush Kumar Gupta, Harish Dureja, Monica Gulati, Sachin Kumar Singh, Gaurav Gupta, Niraj Kumar Jha, Brian Gregory George Oliver, Kamal Dua

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.

Original languageEnglish
Article number109706
Number of pages20
JournalChemico-Biological Interactions
Volume351
DOIs
Publication statusPublished - 5 Jan 2022

Keywords

  • Chronic diseases
  • Drug delivery
  • Lung diseases
  • Nanotechnology
  • Peptides
  • Proteins
  • Respiratory
  • Targeted

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