Protein α-turns recreated in structurally stable small molecules

Huy N. Hoang; Russell W. Driver; Renée L. Beyer; Alpeshkumar K. Malde; Giang T. Le; Giovanni Abbenante; Alan E. Mark; David P. Fairlie

doi:10.1002/anie.201105119

Protein α-turns recreated in structurally stable small molecules

Huy N. Hoang, Russell W. Driver, Renée L. Beyer, Alpeshkumar K. Malde, Giang T. Le, Giovanni Abbenante, Alan E. Mark, David P. Fairlie

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

α-Turn mimics: α-Turns in proteins vary in three sets of (φ, ψ) angles that determine peptide backbone shape and helical pitch. Structures of cyclic tetrapeptides 1 and 2 are shown to closely match two α-turn types that are structurally influential at key sites in 20 proteins described. NMR and CD spectroscopy as well as MD simulations have been used to characterize these first examples of non-helical α-turns created in small molecules.

Original language	English
Pages (from-to)	11107-11111
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	47
DOIs	https://doi.org/10.1002/anie.201105119
Publication status	Published - 18 Nov 2011
Externally published	Yes

Keywords

α-turn
circulardichroism
helices
NMR spectroscopy
peptidomimetics

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10.1002/anie.201105119

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AU - Driver, Russell W.

AU - Beyer, Renée L.

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AU - Le, Giang T.

AU - Abbenante, Giovanni

AU - Mark, Alan E.

AU - Fairlie, David P.

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KW - helices

KW - NMR spectroscopy

KW - peptidomimetics

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Protein α-turns recreated in structurally stable small molecules

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Keywords

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