Protective effects of polydatin against dementia-related disorders

Research output: Contribution to journalReview ArticleOtherpeer-review

14 Citations (Scopus)

Abstract

Dementia is a collection of symptoms affecting a person’s cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against demen-tia-related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.

Original languageEnglish
Pages (from-to)127-135
Number of pages9
JournalCurrent Neuropharmacology
Volume19
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Alzheimer's disease
  • Cognitive dysfunction
  • Dementia
  • Neuroprotection
  • Parkinson's disease
  • Polydatin
  • Resveratrol
  • Vascular dementia

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