TY - JOUR
T1 - Protective effect of embelin against acetic acid induced ulcerative colitis in rats
AU - Thippeswamy, Boreddy Shivanandappa
AU - Mahendran, Sekar
AU - Biradar, Mahantesh I.
AU - Raj, Pooja
AU - Srivastava, Kamya
AU - Badami, Shrishailappa
AU - Veerapur, Veeresh Prabhakar
N1 - Funding Information:
Mahendran S. would like to thank the University Grants Commission, New Delhi, for awarding a Junior Research Fellowship. BST, SB and VPV gratefully acknowledge the financial support by the Vision Group on Science and Technology, Government of Karnataka under the programme for Establishment of Centre of Excellence in Herbal Drug Development (Viya Ei-31 Vitra Ma 2010).
PY - 2011/3/1
Y1 - 2011/3/1
N2 - The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100 mg/kg, p.o.) for five consecutive days before induction of colitis by intra-rectal acetic acid (3% v/v) administration and the treatment continued up to 7 days. The colonic mucosal injury was assessed by clinical, macroscopic, biochemical and histopathological examinations. Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls. The treatment also reduced significantly the colonic myeloperoxidase activity, lipid peroxides and serum lactate dehydrogenase and significantly increased the reduced glutathione. The histopathological studies also confirmed the foregoing findings. The protective effect may be due to its antioxidant and anti-inflammatory activities.
AB - The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100 mg/kg, p.o.) for five consecutive days before induction of colitis by intra-rectal acetic acid (3% v/v) administration and the treatment continued up to 7 days. The colonic mucosal injury was assessed by clinical, macroscopic, biochemical and histopathological examinations. Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls. The treatment also reduced significantly the colonic myeloperoxidase activity, lipid peroxides and serum lactate dehydrogenase and significantly increased the reduced glutathione. The histopathological studies also confirmed the foregoing findings. The protective effect may be due to its antioxidant and anti-inflammatory activities.
KW - Colitis
KW - Crohn's disease
KW - Embelia ribes
KW - Embelin
KW - Inflammatory bowel disease
UR - http://www.scopus.com/inward/record.url?scp=78951474725&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2010.12.012
DO - 10.1016/j.ejphar.2010.12.012
M3 - Article
C2 - 21185828
AN - SCOPUS:78951474725
SN - 0014-2999
VL - 654
SP - 100
EP - 105
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -