Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Daniel Philip Poole, Silvia Amadesi, Nicholas Andrew Veldhuis, Fe C Abogadie, Tina Marie Lieu, William Darby, Wolfgang Liedtke, Michael J Lew, Peter B McIntyre, Nigel William Bunnett

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124 Citations (Scopus)


Background: Receptors activate channels of sensory nerves to cause inflammation and pain by unknown mechanisms. Results: Protease-activated receptor 2 (PAR2) stimulated transient receptor potential vanilloid 4 (TRPV4) by generation of channel agonists. This required a key TRPV4 tyrosine and induced inflammation. Conclusion: PAR2 opens TRPV4 by functional coupling. Significance: Antagonism of PAR2-TRPV4 coupling could alleviate inflammation and pain.
Original languageEnglish
Pages (from-to)5790 - 5802
Number of pages13
JournalJournal of Biological Chemistry
Issue number8
Publication statusPublished - 2013

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