Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis

David Ming Wong, Vivian Tam, Roselind Lam, Katrina A Walsh, Liliana Tatarczuch, Charles N Pagel, Eric Charles Reynolds, Neil M O'Brien-Simpson, Eleanor J Mackie, Robert Neil Pike

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25 Citations (Scopus)


The tissue destruction seen in chronic periodontitis is commonly accepted to involve extensive upregulation of the host inflammatory response. Protease-activated receptor-2 (PAR-2) null mice infected with Porphyromonas gingivalis did not display periodontal bone resorption in contrast to wild type infected and PAR-1 null infected mice. Histological examination of tissues confirmed the lowered bone resorption in PAR-2 null mice and identified a substantial decrease in mast cells infiltrating the periodontal tissues of these mice. T-cells from P. gingivalis infected or immunised PAR-2 null mice proliferated less in response to antigen than those from wild type animals. CD90 (Thy1.2) expression on CD4+ and CD8+ TCRbeta T-cells was significantly (p
Original languageEnglish
Pages (from-to)629 - 638
Number of pages9
JournalInfection and Immunity
Publication statusPublished - 2010

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