Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis

David Ming Wong, Vivian Tam, Roselind Lam, Katrina A Walsh, Liliana Tatarczuch, Charles N Pagel, Eric Charles Reynolds, Neil M O'Brien-Simpson, Eleanor J Mackie, Robert Neil Pike

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19 Citations (Scopus)

Abstract

The tissue destruction seen in chronic periodontitis is commonly accepted to involve extensive upregulation of the host inflammatory response. Protease-activated receptor-2 (PAR-2) null mice infected with Porphyromonas gingivalis did not display periodontal bone resorption in contrast to wild type infected and PAR-1 null infected mice. Histological examination of tissues confirmed the lowered bone resorption in PAR-2 null mice and identified a substantial decrease in mast cells infiltrating the periodontal tissues of these mice. T-cells from P. gingivalis infected or immunised PAR-2 null mice proliferated less in response to antigen than those from wild type animals. CD90 (Thy1.2) expression on CD4+ and CD8+ TCRbeta T-cells was significantly (p
Original languageEnglish
Pages (from-to)629 - 638
Number of pages9
JournalInfection and Immunity
Volume78
DOIs
Publication statusPublished - 2010

Cite this

Wong, D. M., Tam, V., Lam, R., Walsh, K. A., Tatarczuch, L., Pagel, C. N., Reynolds, E. C., O'Brien-Simpson, N. M., Mackie, E. J., & Pike, R. N. (2010). Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis. Infection and Immunity, 78, 629 - 638. https://doi.org/10.1128/IAI.01019-09