Prosthetic Joint Infection: Diagnosis Update

Trisha Nicole Peel, Robin Patel

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The optimal methods to diagnose prosthetic joint infections (PJIs) present a number of significant challenges to clinicians. Conventional methods for detection of infections lack sensitivity and/or specificity.

In recent years, there has been increased research focussing on the optimisation of PJI diagnosis. These improvements include the development of clear, evidence-informed diagnostic criteria to harmonise the definition and classification of PJI. Research has also examined commonly applied serum and synovial inflammatory markers, such as C-reactive protein and synovial leukocyte parameters, to provide further clarity about the optimal cut-offs for these markers in different clinical scenarios. Methods to improve microbiological culture techniques have also been examined, including examination of the ideal specimens and specimen number and culture media and culture duration.

Finally, new markers including synovial leukocyte esterase and synovial alpha-defensin have been developed in attempt to improve the sensitivity and specificity of PJI diagnosis. This chapter will review the current evidence for PJI diagnosis.
Original languageEnglish
Title of host publicationProsthetic Joint Infections
EditorsTrisah Peel
Place of PublicationCham, Switzerland
PublisherSpringer
Chapter3
Pages55-138
Number of pages81
ISBN (Electronic)9783319652504
ISBN (Print)9783319652498
DOIs
Publication statusPublished - 2018

Cite this

Peel, T. N., & Patel, R. (2018). Prosthetic Joint Infection: Diagnosis Update. In T. Peel (Ed.), Prosthetic Joint Infections (pp. 55-138). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-319-65250-4_3
Peel, Trisha Nicole ; Patel, Robin. / Prosthetic Joint Infection : Diagnosis Update. Prosthetic Joint Infections. editor / Trisah Peel. Cham, Switzerland : Springer, 2018. pp. 55-138
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Peel, TN & Patel, R 2018, Prosthetic Joint Infection: Diagnosis Update. in T Peel (ed.), Prosthetic Joint Infections. Springer, Cham, Switzerland, pp. 55-138. https://doi.org/10.1007/978-3-319-65250-4_3

Prosthetic Joint Infection : Diagnosis Update. / Peel, Trisha Nicole; Patel, Robin.

Prosthetic Joint Infections. ed. / Trisah Peel. Cham, Switzerland : Springer, 2018. p. 55-138.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Peel TN, Patel R. Prosthetic Joint Infection: Diagnosis Update. In Peel T, editor, Prosthetic Joint Infections. Cham, Switzerland: Springer. 2018. p. 55-138 https://doi.org/10.1007/978-3-319-65250-4_3