Prostate-specific membrane antigen theranostics in advanced prostate cancer: an evolving option

Nikhil Mayor, Niranjan J. Sathianathen, James Buteau, Samantha Koschel, Marta Antón Juanilla, Jada Kapoor, Arun Azad, Michael S. Hofman, Declan G. Murphy

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Objectives: To review current data for the role of prostate specific membrane antigen (PSMA) radioligand therapy (RLT) for patients with advanced prostate cancer. This review provides an update for multidisciplinary teams on the current and potential future applications of theranostics in prostate cancer. Methods: Narrative review focussing on PSMA as a target for RLT, and data using. Results: RLT with PSMA is an exciting therapeutic alternative to the existing management options already in use for patients with metastatic castrate-resistant prostate cancer (mCRPC). To date, most evidence exists regarding small-molecule PSMA inhibitors bound to beta-emitting radioisotopes such as 177Lu (Lu-PSMA). Prospective phase II data supports the safety and efficacy of Lu-PSMA in men with heavily pre-treated progressive mCRPC, and several late-phase randomised trials of Lu-PSMA are underway, with many more in the pipeline. Early results are encouraging, indicating that the theranostic approach may play a vital role in management of advanced prostate cancer and perhaps even in much earlier disease states. Conclusions: PSMA RLT is a promising new treatment option for men with mCPRC, and may also have utility in less advanced prostate cancer.

Original languageEnglish
Pages (from-to)525-535
Number of pages11
JournalBJU International
Volume126
Issue number5
DOIs
Publication statusPublished - Nov 2020
Externally publishedYes

Keywords

  • #PCSM
  • #ProstateCancer
  • castration resistant
  • lutetium
  • metastatic
  • neoadjuvant
  • prostate cancer
  • prostate-specific membrane antigen
  • theranostics

Cite this