Prostate organogenesis: Tissue induction, hormonal regulation and cell type specification

Roxanne Toivanen, Michael M Shen

Research output: Contribution to journalReview ArticleResearchpeer-review

53 Citations (Scopus)

Abstract

Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.

Original languageEnglish
Pages (from-to)1382-1398
Number of pages17
JournalDevelopment
Volume144
Issue number8
DOIs
Publication statusPublished - 15 Apr 2017
Externally publishedYes

Keywords

  • Androgen signaling
  • Development
  • Differentiation
  • Induction
  • Prostate

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