TY - JOUR
T1 - Prospects of Antiviral Drugs Derived from Natural Products
T2 - Targeting SARS-CoV Entry and Replication
AU - Soon, Tsuey Ning
AU - Yap, Wei Hsum
AU - Lim, Ya Chee
AU - Long, Chiau Ming
AU - Goh, Bey Hing
AU - Tang, Yin Quan
N1 - Funding Information:
This research was funded by Monash Global Asia in the 21st Century (GA21) research grants (GA-HW-19-L01 & GA-HW-19-S02), and Fundamental Research Grant Scheme (FRGS/1/2019/WAB09/MUSM/02/1, FRGS /1/2019/SKK08/TAYLOR/02/2 & FRGS/1/2020 /SKK0/-TAYLOR/02/2).
Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Abstract: The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongo-ing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS-and MER-S-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihy-dromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3-β-d-glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubrano-side A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new an-ti-SARS-CoV-2 drugs.
AB - Abstract: The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongo-ing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS-and MER-S-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihy-dromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3-β-d-glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubrano-side A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new an-ti-SARS-CoV-2 drugs.
KW - 2019-nCoV
KW - Antiviral drugs
KW - COVID-19
KW - MERS-CoV
KW - Natural products
KW - SARS-CoV
KW - SARS-CoV-2
KW - Traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=85125657978&partnerID=8YFLogxK
U2 - 10.2174/2215083807666210122151039
DO - 10.2174/2215083807666210122151039
M3 - Review Article
AN - SCOPUS:85125657978
SN - 2215-0838
VL - 7
JO - Current Traditional Medicine
JF - Current Traditional Medicine
IS - 5
M1 - e220121190624
ER -