TY - JOUR
T1 - Prospects for Leveraging the Microbiota as Medicine for Hypertension
AU - Durgan, David J.
AU - Zubcevic, Jasenka
AU - Vijay-Kumar, Matam
AU - Yang, Tao
AU - Manandhar, Ishan
AU - Aryal, Sachin
AU - Muralitharan, Rikeish R.
AU - Li, Hong Bao
AU - Li, Ying
AU - Abais-Battad, Justine M.
AU - Pluznick, Jennifer L.
AU - Muller, Dominik N.
AU - Marques, Francine Z.
AU - Joe, Bina
N1 - Funding Information:
D.J Durgan was supported by an American Heart Association Transformational Project Award 23TPA1074308 and National Institutes of Health RO1HL134838. M. Vijay-Kumar was supported by National Institutes of Health R01DK134053. T. Yang was supported by an American Heart Association Career Development Award 852969 and National Institutes of Health R21AG079357. H.-B. Li was supported by the National Natural Science Foundation of China 82170443. J.M. Abais-Battad was supported by the American Heart Association Career Development Award CDA34660184. J.L. Pluznick was supported by an American Heart Association Established Investigator Award 34760253 and National Institutes of Health R21AG081683. D.N. Muller was supported by Deutsche Forschungsgemeinschaft (German Research Foundation; DFG-SFB1449) and by Deutsches Zentrum f\u00FCr Herz-Kreislauf-Forschung (81Z0100106). F.Z. Marques is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation, a National Heart Foundation Future Leader Fellowship (105663), and a National Health and Medical Research Council Emerging Leader Fellowship (GNT2017382).
PY - 2024/5/1
Y1 - 2024/5/1
N2 - In 1924, the distinguished Dutch physiologist Willem Einthoven was awarded the Nobel Prize in Physiology or Medicine for his research and invention of the ECG. Coincidentally, the same year marked the birth of the American Heart Association (AHA), whose central mission, as the name indicates, was also focused on heart health. By then, the term essential hypertension (essentielle hypertonie) was already coined by Eberhard Frank to describe elevated blood pressure (BP).1 However, at that time, the relationships between the heart and essential hypertension were murky.2 Fast-forward to 2024, and as we celebrate the centennial year of the AHA, it is clear that essential hypertension persists as the single most significant risk factor for heart diseases, which are the major contributors to human morbidity and mortality. Therefore, finding solutions to curb essential hypertension is central to achieving the mission of the AHA, which is to be a relentless force for a world of longer, healthier lives.
AB - In 1924, the distinguished Dutch physiologist Willem Einthoven was awarded the Nobel Prize in Physiology or Medicine for his research and invention of the ECG. Coincidentally, the same year marked the birth of the American Heart Association (AHA), whose central mission, as the name indicates, was also focused on heart health. By then, the term essential hypertension (essentielle hypertonie) was already coined by Eberhard Frank to describe elevated blood pressure (BP).1 However, at that time, the relationships between the heart and essential hypertension were murky.2 Fast-forward to 2024, and as we celebrate the centennial year of the AHA, it is clear that essential hypertension persists as the single most significant risk factor for heart diseases, which are the major contributors to human morbidity and mortality. Therefore, finding solutions to curb essential hypertension is central to achieving the mission of the AHA, which is to be a relentless force for a world of longer, healthier lives.
KW - blood pressure
KW - essential hypertension
KW - heart diseases
KW - inventions
KW - microbiota
UR - https://www.scopus.com/pages/publications/85190833928
U2 - 10.1161/HYPERTENSIONAHA.124.21721
DO - 10.1161/HYPERTENSIONAHA.124.21721
M3 - Review Article
C2 - 38630799
AN - SCOPUS:85190833928
SN - 0194-911X
VL - 81
SP - 951
EP - 963
JO - Hypertension
JF - Hypertension
IS - 5
ER -