Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity

Olga Niewiadomski; Corrie Studd; Christopher S Hair; Jarrad Wilson; Nik S Ding; Neel Mohan Heerasing; Alvin Ting; John James McNeil; Ross Knight; John Santamaria; Emily Prewett; Paul Dabkowski; Damian Dowling; Sina Alexander; Ben Allen; Benjamin David Popp; William R Connell; Paul V Desmond; Sally Bell

doi:10.1111/jgh.12967

Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity

Olga Niewiadomski, Corrie Studd, Christopher S Hair, Jarrad Wilson, Nik S Ding, Neel Mohan Heerasing, Alvin Ting, John James McNeil, Ross Knight, John Santamaria, Emily Prewett, Paul Dabkowski, Damian Dowling, Sina Alexander, Ben Allen, Benjamin David Popp, William R Connell, Paul V Desmond, Sally Bell

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

66 Citations (Scopus)

Abstract

Background and Aim: We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. Methods: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. Results: We report on the early outcomes (median 18 months, range 12-60 months) for 252 patients comprising 146 with Crohn s disease (CD), 96 with ulcerative colitis (UC), and 10 IBD undifferentiated. Eighty-seven percent of CD patients had inflammatory disease at diagnosis, and this reduced to 73 at 5 years (n=38). Immunomodulators were prescribed in 57 of CD patients and 19 with UC. A third of all CD patients were hospitalized, the majority (77 ) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P

Original language	English
Pages (from-to)	1346 - 1353
Number of pages	8
Journal	Journal of Gastroenterology and Hepatology
Volume	30
Issue number	9
DOIs	https://doi.org/10.1111/jgh.12967
Publication status	Published - 2015

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Niewiadomski, O., Studd, C., Hair, C. S., Wilson, J., Ding, N. S., Heerasing, N. M., Ting, A., McNeil, J. J., Knight, R., Santamaria, J., Prewett, E., Dabkowski, P., Dowling, D., Alexander, S., Allen, B., Popp, B. D., Connell, W. R., Desmond, P. V., & Bell, S. (2015). Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity. Journal of Gastroenterology and Hepatology, 30(9), 1346 - 1353. https://doi.org/10.1111/jgh.12967

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title = "Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity",

abstract = "Background and Aim: We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. Methods: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. Results: We report on the early outcomes (median 18 months, range 12-60 months) for 252 patients comprising 146 with Crohn s disease (CD), 96 with ulcerative colitis (UC), and 10 IBD undifferentiated. Eighty-seven percent of CD patients had inflammatory disease at diagnosis, and this reduced to 73 at 5 years (n=38). Immunomodulators were prescribed in 57 of CD patients and 19 with UC. A third of all CD patients were hospitalized, the majority (77 ) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P",

author = "Olga Niewiadomski and Corrie Studd and Hair, {Christopher S} and Jarrad Wilson and Ding, {Nik S} and Heerasing, {Neel Mohan} and Alvin Ting and McNeil, {John James} and Ross Knight and John Santamaria and Emily Prewett and Paul Dabkowski and Damian Dowling and Sina Alexander and Ben Allen and Popp, {Benjamin David} and Connell, {William R} and Desmond, {Paul V} and Sally Bell",

year = "2015",

doi = "10.1111/jgh.12967",

language = "English",

volume = "30",

pages = "1346 -- 1353",

journal = "Journal of Gastroenterology and Hepatology",

issn = "0815-9319",

publisher = "Wiley-Blackwell",

number = "9",

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Niewiadomski, O, Studd, C, Hair, CS, Wilson, J, Ding, NS, Heerasing, NM, Ting, A, McNeil, JJ, Knight, R, Santamaria, J, Prewett, E, Dabkowski, P, Dowling, D, Alexander, S, Allen, B, Popp, BD, Connell, WR, Desmond, PV & Bell, S 2015, 'Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity', Journal of Gastroenterology and Hepatology, vol. 30, no. 9, pp. 1346 - 1353. https://doi.org/10.1111/jgh.12967

TY - JOUR

T1 - Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity

AU - Niewiadomski, Olga

AU - Studd, Corrie

AU - Hair, Christopher S

AU - Wilson, Jarrad

AU - Ding, Nik S

AU - Heerasing, Neel Mohan

AU - Ting, Alvin

AU - McNeil, John James

AU - Knight, Ross

AU - Santamaria, John

AU - Prewett, Emily

AU - Dabkowski, Paul

AU - Dowling, Damian

AU - Alexander, Sina

AU - Allen, Ben

AU - Popp, Benjamin David

AU - Connell, William R

AU - Desmond, Paul V

AU - Bell, Sally

PY - 2015

Y1 - 2015

N2 - Background and Aim: We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. Methods: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. Results: We report on the early outcomes (median 18 months, range 12-60 months) for 252 patients comprising 146 with Crohn s disease (CD), 96 with ulcerative colitis (UC), and 10 IBD undifferentiated. Eighty-seven percent of CD patients had inflammatory disease at diagnosis, and this reduced to 73 at 5 years (n=38). Immunomodulators were prescribed in 57 of CD patients and 19 with UC. A third of all CD patients were hospitalized, the majority (77 ) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P

AB - Background and Aim: We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. Methods: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. Results: We report on the early outcomes (median 18 months, range 12-60 months) for 252 patients comprising 146 with Crohn s disease (CD), 96 with ulcerative colitis (UC), and 10 IBD undifferentiated. Eighty-seven percent of CD patients had inflammatory disease at diagnosis, and this reduced to 73 at 5 years (n=38). Immunomodulators were prescribed in 57 of CD patients and 19 with UC. A third of all CD patients were hospitalized, the majority (77 ) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P

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U2 - 10.1111/jgh.12967

DO - 10.1111/jgh.12967

M3 - Article

SN - 0815-9319

VL - 30

SP - 1346

EP - 1353

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

IS - 9

ER -

Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity

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