Prospective population-based cohort of inflammatory bowel disease in the biologics era: disease course and predictors of severity

Olga Niewiadomski, Corrie Studd, Christopher S Hair, Jarrad Wilson, Nik S Ding, Neel Mohan Heerasing, Alvin Ting, John James McNeil, Ross Knight, John Santamaria, Emily Prewett, Paul Dabkowski, Damian Dowling, Sina Alexander, Ben Allen, Benjamin David Popp, William R Connell, Paul V Desmond, Sally Bell

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42 Citations (Scopus)

Abstract

Background and Aim: We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. Methods: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. Results: We report on the early outcomes (median 18 months, range 12-60 months) for 252 patients comprising 146 with Crohn s disease (CD), 96 with ulcerative colitis (UC), and 10 IBD undifferentiated. Eighty-seven percent of CD patients had inflammatory disease at diagnosis, and this reduced to 73 at 5 years (n=38). Immunomodulators were prescribed in 57 of CD patients and 19 with UC. A third of all CD patients were hospitalized, the majority (77 ) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P
Original languageEnglish
Pages (from-to)1346 - 1353
Number of pages8
JournalJournal of Gastroenterology and Hepatology
Volume30
Issue number9
DOIs
Publication statusPublished - 2015

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