Abstract
Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.
| Original language | English |
|---|---|
| Pages (from-to) | 65-71 |
| Number of pages | 7 |
| Journal | Experimental Gerontology |
| Volume | 118 |
| DOIs | |
| Publication status | Published - 1 Apr 2019 |
Keywords
- Body composition
- Health-related quality of life
- Muscle mass
- Muscle strength
Cite this
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Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults. / Balogun, Saliu; Winzenberg, Tania; Wills, Karen; Scott, David; Jones, Graeme; Callisaya, Michele L.; Aitken, Dawn.
In: Experimental Gerontology, Vol. 118, 01.04.2019, p. 65-71.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults
AU - Balogun, Saliu
AU - Winzenberg, Tania
AU - Wills, Karen
AU - Scott, David
AU - Jones, Graeme
AU - Callisaya, Michele L.
AU - Aitken, Dawn
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.
AB - Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.
KW - Body composition
KW - Health-related quality of life
KW - Muscle mass
KW - Muscle strength
UR - http://www.scopus.com/inward/record.url?scp=85059949592&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2019.01.008
DO - 10.1016/j.exger.2019.01.008
M3 - Article
VL - 118
SP - 65
EP - 71
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -