Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults

Saliu Balogun, Tania Winzenberg, Karen Wills, David Scott, Graeme Jones, Michele L. Callisaya, Dawn Aitken

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalExperimental Gerontology
Volume118
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Body composition
  • Health-related quality of life
  • Muscle mass
  • Muscle strength

Cite this

@article{31cd7c94e2a9480484753ef504866f75,
title = "Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults",
abstract = "Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51{\%} women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20{\%} of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95{\%} CI: −0.089, −0.033) and women (β = −0.089, 95{\%} CI: −0.129, −0.049) but not men (β = −0.023, 95{\%} CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95{\%} CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.",
keywords = "Body composition, Health-related quality of life, Muscle mass, Muscle strength",
author = "Saliu Balogun and Tania Winzenberg and Karen Wills and David Scott and Graeme Jones and Callisaya, {Michele L.} and Dawn Aitken",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.exger.2019.01.008",
language = "English",
volume = "118",
pages = "65--71",
journal = "Experimental Gerontology",
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Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults. / Balogun, Saliu; Winzenberg, Tania; Wills, Karen; Scott, David; Jones, Graeme; Callisaya, Michele L.; Aitken, Dawn.

In: Experimental Gerontology, Vol. 118, 01.04.2019, p. 65-71.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults

AU - Balogun, Saliu

AU - Winzenberg, Tania

AU - Wills, Karen

AU - Scott, David

AU - Jones, Graeme

AU - Callisaya, Michele L.

AU - Aitken, Dawn

PY - 2019/4/1

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N2 - Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.

AB - Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years. Results: Participants with LMSLOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.

KW - Body composition

KW - Health-related quality of life

KW - Muscle mass

KW - Muscle strength

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