Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults

Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults. Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMI_LOW), LMS (LMS_LOW) and HGS (HGS_LOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMI_LOW, LMS_LOW, and HGS_LOW at baseline and HRQoL over 10 years. Results: Participants with LMS_LOW (β = −0.061, 95% CI: −0.089, −0.033) and women (β = −0.089, 95% CI: −0.129, −0.049) but not men (β = −0.023, 95% CI: −0.064, 0.019) with HGS_LOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMI_LOW and 10-year HRQoL (β = −0.038, 95% CI: −0.068, −0.008). Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.