TY - JOUR
T1 - Prospective approach of Swietenia macrophylla as a neuroprotective agent for Alzheimer's Disease
T2 - Emphasis on ameliorative mechanism
AU - Jazuli, Imrana
AU - Hing, Goh Bey
AU - Selvaratnam, Lakshmi
AU - Han, Lee Learn
AU - Alex, Deepa
AU - Kumari, Yatinesh
N1 - Funding Information:
We thank Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia , for the financial support ( I-M010-SED-000168 - School SEED Grant) to our work on the neuroprotective potential of Swietenia macrophylla to ameliorate Alzheimer’s disease pathology, which was the starting point of this review article.
Publisher Copyright:
© 2023 The Authors
PY - 2023/9
Y1 - 2023/9
N2 - Alzheimer's disease (AD) poses a significant challenge to healthcare systems and economics worldwide in the 21st century. It is characterised by progressive memory dysfunction and is a leading cause of dementia. Literature suggests that the involvement of neuroinflammation plays a critical role in the progression of neuropathological changes in AD. Currently, available drugs for AD management primarily focus on symptomatic treatment. There is a need for safe adjunctive agents with a specific target and explicit mechanism of action. Swietenia macrophylla (SM) has been traditionally used as a food source and for pain relief in folk medicine. Recent studies have highlighted the neuroprotective properties of SM, including its anti-inflammatory, antioxidant, anti-acetylcholinesterase, and anti-mitochondrial dysfunction effects. In light of these considerations, this review aims to explore the potential neuroprotective role of SM by examining the existing literature to elucidate its potential mechanisms of action in addressing the complex challenges presented by AD.
AB - Alzheimer's disease (AD) poses a significant challenge to healthcare systems and economics worldwide in the 21st century. It is characterised by progressive memory dysfunction and is a leading cause of dementia. Literature suggests that the involvement of neuroinflammation plays a critical role in the progression of neuropathological changes in AD. Currently, available drugs for AD management primarily focus on symptomatic treatment. There is a need for safe adjunctive agents with a specific target and explicit mechanism of action. Swietenia macrophylla (SM) has been traditionally used as a food source and for pain relief in folk medicine. Recent studies have highlighted the neuroprotective properties of SM, including its anti-inflammatory, antioxidant, anti-acetylcholinesterase, and anti-mitochondrial dysfunction effects. In light of these considerations, this review aims to explore the potential neuroprotective role of SM by examining the existing literature to elucidate its potential mechanisms of action in addressing the complex challenges presented by AD.
KW - Alzheimer's Disease
KW - Antioxidant
KW - Neuroinflammation
KW - Neuroprotection
KW - Swietenia macrophylla
UR - http://www.scopus.com/inward/record.url?scp=85170103054&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2023.105764
DO - 10.1016/j.jff.2023.105764
M3 - Review Article
AN - SCOPUS:85170103054
SN - 1756-4646
VL - 108
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 105764
ER -