Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease

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Abstract

The renin angiotensin system (RAS) is a treatment target for diabetic retinopathy and possibly other ocular diseases. However, angiotensin II blockade, though beneficial in diabetic retinopathy, is not completely retinoprotective. There is speculation that this shortfall is due to incomplete suppression of other RAS components. This review discusses the possibility that prorenin, which initiates the RAS, and the (pro)renin receptor [(P)RR] are potential candidates.
Original languageEnglish
Pages (from-to)69 - 76
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume20
Issue number1
DOIs
Publication statusPublished - 2011

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