TY - JOUR
T1 - Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease
AU - Wilkinson-Berka, Jennifer
AU - Miller, Antonia
AU - Binger, Katrina
PY - 2011
Y1 - 2011
N2 - The renin angiotensin system (RAS) is a treatment target for diabetic retinopathy and possibly other ocular diseases. However, angiotensin II blockade, though beneficial in diabetic retinopathy, is not completely retinoprotective. There is speculation that this shortfall is due to incomplete suppression of other RAS components. This review discusses the possibility that prorenin, which initiates the RAS, and the (pro)renin receptor [(P)RR] are potential candidates.
AB - The renin angiotensin system (RAS) is a treatment target for diabetic retinopathy and possibly other ocular diseases. However, angiotensin II blockade, though beneficial in diabetic retinopathy, is not completely retinoprotective. There is speculation that this shortfall is due to incomplete suppression of other RAS components. This review discusses the possibility that prorenin, which initiates the RAS, and the (pro)renin receptor [(P)RR] are potential candidates.
UR - http://journals.lww.com/co-nephrolhypertens/toc/2011/01000
U2 - 10.1097/MNH.0b013e328341328a
DO - 10.1097/MNH.0b013e328341328a
M3 - Article
SN - 1062-4821
VL - 20
SP - 69
EP - 76
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
IS - 1
ER -
