TY - JOUR
T1 - Propolis
T2 - The future therapy against Helicobacter pylori-mediated gastrointestinal diseases
AU - Shapla, Ummay Mahfuza
AU - Raihan, Jinat
AU - Islam, Asiful
AU - Alam, Fahmida
AU - Solayman, Naeem
AU - Gan, Siew Hua
AU - Hossen, Sakib
AU - Khalil, Ibrahim
N1 - Funding Information:
We would like to acknowledge University Sains Malaysia (USM) Vice-Chancellor Award (2015/2016) and USM Global Fellowship (2014/2015) awarded to Md. Asiful Islam and Fahmida Alam, respectively, to pursue their PhD degrees. We also acknowledge the Research University Grant (RUT) ( 1001/PPSP/853005 ) for providing some financial support.
Publisher Copyright:
© 2017 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very effective in eradicating H. pylori infections. The quest for an alternative treatment free of these inconveniences is currently in demand. One of the important alternatives is propolis, produced by the honeybee Apis mellifera, which has been used to treat different diseases since it possesses a wide range of biochemical properties. Propolis has been reported as a useful therapeutic regimen against H. pylori, which is an important cause of gastric inflammation, peptic ulcer, gastric cancer, and lymphomas of mucosa-associated lymphoid tissues. Apart from propolis, various active compounds of other natural products have also been confirmed to be effective. This review compiles the scientific evidence of the role of propolis and other natural products against H. pylori-associated gastrointestinal tract-related health complexities by acing as an anti-angiogenic, anti-inflammatory, and antioxidant factor as well as via modulation of enzymatic activities.
AB - Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very effective in eradicating H. pylori infections. The quest for an alternative treatment free of these inconveniences is currently in demand. One of the important alternatives is propolis, produced by the honeybee Apis mellifera, which has been used to treat different diseases since it possesses a wide range of biochemical properties. Propolis has been reported as a useful therapeutic regimen against H. pylori, which is an important cause of gastric inflammation, peptic ulcer, gastric cancer, and lymphomas of mucosa-associated lymphoid tissues. Apart from propolis, various active compounds of other natural products have also been confirmed to be effective. This review compiles the scientific evidence of the role of propolis and other natural products against H. pylori-associated gastrointestinal tract-related health complexities by acing as an anti-angiogenic, anti-inflammatory, and antioxidant factor as well as via modulation of enzymatic activities.
KW - Gastrointestinal diseases
KW - H. pylori
KW - Microbial infections
KW - Natural products
KW - Propolis
UR - http://www.scopus.com/inward/record.url?scp=85032940787&partnerID=8YFLogxK
U2 - 10.1016/j.jab.2017.10.007
DO - 10.1016/j.jab.2017.10.007
M3 - Review Article
AN - SCOPUS:85032940787
SN - 1214-021X
VL - 16
SP - 81
EP - 99
JO - Journal of Applied Biomedicine
JF - Journal of Applied Biomedicine
IS - 2
ER -
