Properties and immune function of cardiac fibroblasts

Milena B. Furtado, Muneer Hasham

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

4 Citations (Scopus)

Abstract

This chapter will discuss the role of cardiac fibroblasts as a target of various immunological inputs as well as an immunomodulatory hub of the heart through interaction with immune cell types and chemokine or cytokine signaling. While the purpose of this chapter is to explore the immunomodulatory properties of cardiac fibroblasts, it is important to note that cardiac fibroblasts are not a homogeneous cell type, but have a unique embryological origin and molecular identity. Specific properties of cardiac fibroblasts may influence the way they interact with the heart microenvironment to promote healthy homeostatic function or respond to pathological insults. Therefore, we will briefly discuss these aspects of cardiac fibroblast biology and then focus on their immunomodulatory role in the heart.

Original languageEnglish
Title of host publicationThe Immunology of Cardiovascular Homeostasis and Pathology
EditorsSusanne Sattler, Teresa Kennedy-Lydon
PublisherSpringer
Chapter3
Pages35-70
Number of pages36
Volume1003
ISBN (Electronic)9783319576138
ISBN (Print)9783319576114
DOIs
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1003
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cardiovascular disease
  • Fibroblast
  • Heart
  • Immune response
  • Immunomodulator
  • Injury
  • Myofibroblast

Cite this

Furtado, M. B., & Hasham, M. (2017). Properties and immune function of cardiac fibroblasts. In S. Sattler, & T. Kennedy-Lydon (Eds.), The Immunology of Cardiovascular Homeostasis and Pathology (Vol. 1003, pp. 35-70). (Advances in Experimental Medicine and Biology; Vol. 1003). Springer. https://doi.org/10.1007/978-3-319-57613-8_3