Propensity score-matched analysis of lesion patterns in stroke patients with patent foramen ovale and patients with spontaneous intracranial artery dissection

Yangyang Huang, Yifan Cheng, Bei Shao, Xuanyou Zhou, Huazheng Liang, Jianhua Zhuang, Yong Bi

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Abstract

Aims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD). Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients with PFO and 29 with SIAD. To reduce selection bias, we conducted a propensity score-matching analysis. The patients' propensity scores were estimated using a logistic regression model based on the following variables: age, sex, hypertension, diabetes mellitus, hypercholesterolemia, cigarette smoking, stroke histories, and their NIHSS scores. We compared the pattern of cerebral DWI lesions between patients with PFO and those with SIAD. Results: After propensity score matching, 21 pairs of patients were selected. Clinical characteristics of the 2 groups were well matched. The distribution of DWI lesion patterns differed between the 2 groups. Single lesions (cortical or subcortical) were more frequently observed in the PFO group than in the SIAD group (P = 0.026). Multiple lesions in one vascular territory occurred more frequently in the SIAD group than in the PFO group (P = 0.035). Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes.

Original languageEnglish
Article number418
Number of pages8
JournalFrontiers in Neurology
Volume10
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • DWI
  • Embolism
  • Ischemic stroke
  • Patent foramen ovale
  • Spontaneous intracranial artery dissection

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