Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation

T. E. Gureyev, Ya. I. Nesterets, P. M. Baran, S. T. Taba, S. C. Mayo, D. Thompson, B. D. Arhatari, Alira Mihocic, B. Abbey, D. Lockie, J. Fox, B. Kumar, Z. Prodanovic, D. Hausermann, A. Maksimenko, C. Hall, A. G. Peele, M. Dimmock, K. M. Pavlov, M. Cholewa & 4 others S. Lewis, G. Tromba, H. M. Quiney, P. C. Brennan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Propagation-based phase-contrast computed tomography (PB-CT) is a method for threedimensional X-ray imaging that utilizes refraction, as well as absorption, of X-rays in the tissues to increase the signal-to-noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption-only X-ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods: Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption-only CT and PB-CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB-CT image stacks. Results: Despite the presence of some image artefacts, the PB-CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB-CT imaging and previous reported experimental studies of this imaging modality. Conclusions: The results presented in this paper demonstrate that PB-CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical X-ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB-CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis.
Original languageEnglish
Number of pages29
JournalMedical Physics
DOIs
Publication statusAccepted/In press - 1 Oct 2019

Cite this

Gureyev, T. E., Nesterets, Y. I., Baran, P. M., Taba, S. T., Mayo, S. C., Thompson, D., ... Brennan, P. C. (Accepted/In press). Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation. Medical Physics. https://doi.org/10.1002/mp.13842
Gureyev, T. E. ; Nesterets, Ya. I. ; Baran, P. M. ; Taba, S. T. ; Mayo, S. C. ; Thompson, D. ; Arhatari, B. D. ; Mihocic, Alira ; Abbey, B. ; Lockie, D. ; Fox, J. ; Kumar, B. ; Prodanovic, Z. ; Hausermann, D. ; Maksimenko, A. ; Hall, C. ; Peele, A. G. ; Dimmock, M. ; Pavlov, K. M. ; Cholewa, M. ; Lewis, S. ; Tromba, G. ; Quiney, H. M. ; Brennan, P. C. / Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation. In: Medical Physics. 2019.
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title = "Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation",
abstract = "Purpose: Propagation-based phase-contrast computed tomography (PB-CT) is a method for threedimensional X-ray imaging that utilizes refraction, as well as absorption, of X-rays in the tissues to increase the signal-to-noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption-only X-ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods: Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption-only CT and PB-CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB-CT image stacks. Results: Despite the presence of some image artefacts, the PB-CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB-CT imaging and previous reported experimental studies of this imaging modality. Conclusions: The results presented in this paper demonstrate that PB-CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical X-ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB-CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis.",
author = "Gureyev, {T. E.} and Nesterets, {Ya. I.} and Baran, {P. M.} and Taba, {S. T.} and Mayo, {S. C.} and D. Thompson and Arhatari, {B. D.} and Alira Mihocic and B. Abbey and D. Lockie and J. Fox and B. Kumar and Z. Prodanovic and D. Hausermann and A. Maksimenko and C. Hall and Peele, {A. G.} and M. Dimmock and Pavlov, {K. M.} and M. Cholewa and S. Lewis and G. Tromba and Quiney, {H. M.} and Brennan, {P. C.}",
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Gureyev, TE, Nesterets, YI, Baran, PM, Taba, ST, Mayo, SC, Thompson, D, Arhatari, BD, Mihocic, A, Abbey, B, Lockie, D, Fox, J, Kumar, B, Prodanovic, Z, Hausermann, D, Maksimenko, A, Hall, C, Peele, AG, Dimmock, M, Pavlov, KM, Cholewa, M, Lewis, S, Tromba, G, Quiney, HM & Brennan, PC 2019, 'Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation', Medical Physics. https://doi.org/10.1002/mp.13842

Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation. / Gureyev, T. E.; Nesterets, Ya. I.; Baran, P. M.; Taba, S. T.; Mayo, S. C.; Thompson, D.; Arhatari, B. D.; Mihocic, Alira; Abbey, B.; Lockie, D.; Fox, J.; Kumar, B.; Prodanovic, Z.; Hausermann, D.; Maksimenko, A.; Hall, C.; Peele, A. G.; Dimmock, M.; Pavlov, K. M.; Cholewa, M.; Lewis, S.; Tromba, G.; Quiney, H. M.; Brennan, P. C.

In: Medical Physics, 01.10.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Propagation-based X-ray phase-contrast tomography of mastectomy samples using synchrotron radiation

AU - Gureyev, T. E.

AU - Nesterets, Ya. I.

AU - Baran, P. M.

AU - Taba, S. T.

AU - Mayo, S. C.

AU - Thompson, D.

AU - Arhatari, B. D.

AU - Mihocic, Alira

AU - Abbey, B.

AU - Lockie, D.

AU - Fox, J.

AU - Kumar, B.

AU - Prodanovic, Z.

AU - Hausermann, D.

AU - Maksimenko, A.

AU - Hall, C.

AU - Peele, A. G.

AU - Dimmock, M.

AU - Pavlov, K. M.

AU - Cholewa, M.

AU - Lewis, S.

AU - Tromba, G.

AU - Quiney, H. M.

AU - Brennan, P. C.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Purpose: Propagation-based phase-contrast computed tomography (PB-CT) is a method for threedimensional X-ray imaging that utilizes refraction, as well as absorption, of X-rays in the tissues to increase the signal-to-noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption-only X-ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods: Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption-only CT and PB-CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB-CT image stacks. Results: Despite the presence of some image artefacts, the PB-CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB-CT imaging and previous reported experimental studies of this imaging modality. Conclusions: The results presented in this paper demonstrate that PB-CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical X-ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB-CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis.

AB - Purpose: Propagation-based phase-contrast computed tomography (PB-CT) is a method for threedimensional X-ray imaging that utilizes refraction, as well as absorption, of X-rays in the tissues to increase the signal-to-noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption-only X-ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods: Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption-only CT and PB-CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB-CT image stacks. Results: Despite the presence of some image artefacts, the PB-CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB-CT imaging and previous reported experimental studies of this imaging modality. Conclusions: The results presented in this paper demonstrate that PB-CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical X-ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB-CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis.

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DO - 10.1002/mp.13842

M3 - Article

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

ER -