Propagation-based phase-contrast tomography of a Guinea pig inner ear with cochlear implant using a model-based iterative reconstruction algorithm

Lorenz Hehn, Regine Gradl, Andrej Voss, Benedikt Günther, Martin Dierolf, Christoph Jud, Konstantin Willer, Sebastian Allner, Jörg U. Hammel, Roland Hessler, Kaye S. Morgan, Julia Herzen, Werner Hemmert, Franz Pfeiffer

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Propagation-based phase-contrast computed tomography has become a valuable tool for visualization of three-dimensional biological samples, due to its high contrast between materials with similar attenuation properties. However, one of the most-widely used phase-retrieval algorithms imposes a homogeneity assumption onto the sample, which leads to artifacts for numerous applications where this assumption is violated. Prominent examples are biological samples with highly-absorbing implants. Using synchrotron radiation, we demonstrate by the example of a guinea pig inner ear with a cochlear implant electrode, how a recently developed model-based iterative algorithm for propagation-based phase-contrast computed tomography yields distinct benefits for such a task. We find that the model-based approach improves the overall image quality, removes the detrimental influence of the implant and accurately visualizes the cochlea.

Original languageEnglish
Article number#337870
Pages (from-to)5330-5339
Number of pages10
JournalBiomedical Optics Express
Issue number11
Publication statusPublished - 1 Nov 2018
  • Regine Gradl

    Kaye Morgan (Fellow) & Regine Gradl (Fellow)

    1 Jul 20156 Nov 2019

    Activity: External Academic EngagementExternal HDR Supervision

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