Promotion to trophoblast stem cell proliferation by FGF4

Satoshi Tanaka, Tilo Kunath, Anna Katerina Hadjantonakis, Andras Nagy, Janet Rossant

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1133 Citations (Scopus)


The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocyts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

Original languageEnglish
Pages (from-to)2072-2075
Number of pages4
Issue number5396
Publication statusPublished - 11 Dec 1998
Externally publishedYes

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