Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1 - 10 |
| Number of pages | 10 |
| Journal | PLoS ONE |
| Volume | 9 |
| Issue number | 3 (Art. No: e92042) |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. / Andreassen, Kim Vietz; Hjuler, Sara Toftegaard; Furness, Sebastian G B; Sexton, Patrick M; Christopoulos, Arthur; Nosjean, Olivier; Karsdal, Morten Asser; Henriksen, Kim.
In: PLoS ONE, Vol. 9, No. 3 (Art. No: e92042), 2014, p. 1 - 10.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias
AU - Andreassen, Kim Vietz
AU - Hjuler, Sara Toftegaard
AU - Furness, Sebastian G B
AU - Sexton, Patrick M
AU - Christopoulos, Arthur
AU - Nosjean, Olivier
AU - Karsdal, Morten Asser
AU - Henriksen, Kim
PY - 2014
Y1 - 2014
N2 - Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT(a)R) with respect to activation of cAMP signaling, beta-arrestin recruitment, ligand binding kinetics and internalization. The study was conducted using mammalian cell lines heterologously expressing the human CT(a) receptor. CT(a)R downstream signaling was investigated with dose response profiles for cAMP production and beta-arrestin recruitment for sCT and hCT during short term (
AB - Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT(a)R) with respect to activation of cAMP signaling, beta-arrestin recruitment, ligand binding kinetics and internalization. The study was conducted using mammalian cell lines heterologously expressing the human CT(a) receptor. CT(a)R downstream signaling was investigated with dose response profiles for cAMP production and beta-arrestin recruitment for sCT and hCT during short term (
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958426/pdf/pone.0092042.pdf
U2 - 10.1371/journal.pone.0092042
DO - 10.1371/journal.pone.0092042
M3 - Article
VL - 9
SP - 1
EP - 10
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 3 (Art. No: e92042)
ER -