TY - JOUR
T1 - Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects
AU - Copolov, David L.
AU - Keks, Nicholas A.
AU - Kulkarni, Jayashri
AU - Singh, Bruce S.
AU - McKenzie, Dean
AU - McGorry, Patrick
AU - Hill, Christine
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n=27) had a lower prolactin response to haloperidol than did the controls (n=28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n=7), and those with other psychoses (n=12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia.
AB - Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n=27) had a lower prolactin response to haloperidol than did the controls (n=28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n=7), and those with other psychoses (n=12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=0025034381&partnerID=8YFLogxK
U2 - 10.1016/0306-4530(90)90033-6
DO - 10.1016/0306-4530(90)90033-6
M3 - Article
C2 - 2255750
AN - SCOPUS:0025034381
VL - 15
SP - 225
EP - 231
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
IS - 3
ER -
