Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction

Michelle M Richardson; Julie R Jonsson; Elizabeth E Powell; Elizabeth M Brunt; Brent A Neuschwander-Tetri; Prithi S Bhathal; John Dixon; Martin D Weltman; Herbert Tilg; Alexander R Moschen; David M Purdie; Anthony J Demetris; Andrew D Clouston

Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction

Michelle M Richardson, Julie R Jonsson, Elizabeth E Powell, Elizabeth M Brunt, Brent A Neuschwander-Tetri, Prithi S Bhathal, John Dixon, Martin D Weltman, Herbert Tilg, Alexander R Moschen, David M Purdie, Anthony J Demetris, Andrew D Clouston

Research output: Contribution to journal › Article › Research › peer-review

432 Citations (Scopus)

Abstract

Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and poorly understood. Fatty liver has impaired regeneration that induces a secondary replicative pathway using bipotential, periportal, hepatic progenitor cells (HPCs). We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus

Original language	English
Pages (from-to)	80 - 90
Number of pages	11
Journal	Gastroenterology
Volume	133
Issue number	1
Publication status	Published - 2007

Cite this

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title = "Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction",

abstract = "Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and poorly understood. Fatty liver has impaired regeneration that induces a secondary replicative pathway using bipotential, periportal, hepatic progenitor cells (HPCs). We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus",

author = "Richardson, {Michelle M} and Jonsson, {Julie R} and Powell, {Elizabeth E} and Brunt, {Elizabeth M} and Neuschwander-Tetri, {Brent A} and Bhathal, {Prithi S} and John Dixon and Weltman, {Martin D} and Herbert Tilg and Moschen, {Alexander R} and Purdie, {David M} and Demetris, {Anthony J} and Clouston, {Andrew D}",

year = "2007",

language = "English",

volume = "133",

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T1 - Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction

AU - Richardson, Michelle M

AU - Jonsson, Julie R

AU - Powell, Elizabeth E

AU - Brunt, Elizabeth M

AU - Neuschwander-Tetri, Brent A

AU - Bhathal, Prithi S

AU - Dixon, John

AU - Weltman, Martin D

AU - Tilg, Herbert

AU - Moschen, Alexander R

AU - Purdie, David M

AU - Demetris, Anthony J

AU - Clouston, Andrew D

PY - 2007

Y1 - 2007

N2 - Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and poorly understood. Fatty liver has impaired regeneration that induces a secondary replicative pathway using bipotential, periportal, hepatic progenitor cells (HPCs). We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus

AB - Portal fibrosis and linkage is a key feature of progressive disease in nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and poorly understood. Fatty liver has impaired regeneration that induces a secondary replicative pathway using bipotential, periportal, hepatic progenitor cells (HPCs). We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus

UR - http://www.ncbi.nlm.nih.gov/pubmed/17631134

M3 - Article

SN - 0016-5085

VL - 133

SP - 80

EP - 90

JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction

Abstract

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