Progress in mitochondrial replacement therapies

Mary Herbert; Doug Turnbull

doi:10.1038/nrm.2018.3

Progress in mitochondrial replacement therapies

Mary Herbert
, Doug Turnbull

Research output: Contribution to journal › Comment / Debate › Other › peer-review

62 Citations (Scopus)

Abstract

Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

Original language	English
Pages (from-to)	71-72
Number of pages	2
Journal	Nature Reviews Molecular Cell Biology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1038/nrm.2018.3
Publication status	Published - Feb 2018
Externally published	Yes

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10.1038/nrm.2018.3

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title = "Progress in mitochondrial replacement therapies",

abstract = "Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.",

author = "Mary Herbert and Doug Turnbull",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is funded by grants from The Wellcome Centre for Mitochondrial Research, Medical Research Council, EU Horizon 2020 and the UK NIHR Biomedical Research Centre awarded to Newcastle upon Tyne NHS Trust. Publisher Copyright: {\textcopyright} 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",

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AU - Turnbull, Doug

N1 - Funding Information: Work in the authors’ laboratories is funded by grants from The Wellcome Centre for Mitochondrial Research, Medical Research Council, EU Horizon 2020 and the UK NIHR Biomedical Research Centre awarded to Newcastle upon Tyne NHS Trust. Publisher Copyright: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

PY - 2018/2

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N2 - Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

AB - Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

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U2 - 10.1038/nrm.2018.3

DO - 10.1038/nrm.2018.3

M3 - Comment / Debate

C2 - 29358685

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VL - 19

SP - 71

EP - 72

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

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Progress in mitochondrial replacement therapies

Abstract

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