Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction (PROTECT-ICD): Trial Protocol, Background and Significance

Sarah Zaman, Andrew J. Taylor, Martin K. Stiles, Clara Chow, Pramesh Kovoor

Research output: Contribution to journalReview ArticleOtherpeer-review

18 Citations (Scopus)

Abstract

The ‘Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction’ (PROTECT-ICD) trial is an Australian-led multicentre randomised controlled trial targeting prevention of sudden cardiac death in patients who have at least moderately reduced cardiac function following a myocardial infarct (MI). The primary objective of the trial is to assess whether electrophysiological study to guide prophylactic implantation of an implantable cardioverter-defibrillator (ICD) early following MI (first 40 days) will lead to a significant reduction in sudden cardiac death and non-fatal arrhythmia. The secondary objective is to assess the utility of cardiac MRI (CMR) in assessing early myocardial characteristics, and its predictive value for both inducible ventricular tachycardia (VT) at EPS and SCD/ non-fatal arrhythmia at follow-up.

Original languageEnglish
Pages (from-to)1055-1062
Number of pages8
JournalHeart Lung and Circulation
Volume25
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Implantable-cardioverter defibrillator
  • Myocardial infarction
  • Primary prevention
  • Randomised controlled trial
  • Sudden cardiac death

Cite this