Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury

a systematic review

Eric Mercier, Pier Alexandre Tardif, Peter A. Cameron, Marcel Émond, Lynne Moore, Biswadev Mitra, Marie Christine Ouellet, Jérôme Frenette, Elaine de Guise, Natalie Le Sage

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Background: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). Methods: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. Results: The search strategy yielded a total of 23,298 citations from which 8 cohorts presented in 10 studies were included. Studies included between 45 and 141 patients (total 608 patients). The outcomes most frequently assessed were post-concussion syndrome (PCS, 12 assessments) and neuropsychological performance deficits (10 assessments). No association was found between an elevated NSE serum level and PCS. Only one study reported a statistically significant association between a higher NSE serum level and alteration of at least three cognitive domains at 2 weeks but this association was no longer significant at 6 weeks. Overall, risk of bias of the included studies was considered moderate. Conclusions: Early NSE serum level is not a strong independent predictor of post-concussion symptoms following mild TBI.

Original languageEnglish
Pages (from-to)29-40
Number of pages12
JournalBrain Injury
Volume32
Issue number1
DOIs
Publication statusPublished - 2 Jan 2018

Keywords

  • Biomarker
  • neuron-specific enolase
  • post-concussion symptoms
  • post-concussion syndrome
  • systematic review
  • traumatic brain injury

Cite this

Mercier, Eric ; Tardif, Pier Alexandre ; Cameron, Peter A. ; Émond, Marcel ; Moore, Lynne ; Mitra, Biswadev ; Ouellet, Marie Christine ; Frenette, Jérôme ; de Guise, Elaine ; Le Sage, Natalie. / Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury : a systematic review. In: Brain Injury. 2018 ; Vol. 32, No. 1. pp. 29-40.
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title = "Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review",
abstract = "Background: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). Methods: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. Results: The search strategy yielded a total of 23,298 citations from which 8 cohorts presented in 10 studies were included. Studies included between 45 and 141 patients (total 608 patients). The outcomes most frequently assessed were post-concussion syndrome (PCS, 12 assessments) and neuropsychological performance deficits (10 assessments). No association was found between an elevated NSE serum level and PCS. Only one study reported a statistically significant association between a higher NSE serum level and alteration of at least three cognitive domains at 2 weeks but this association was no longer significant at 6 weeks. Overall, risk of bias of the included studies was considered moderate. Conclusions: Early NSE serum level is not a strong independent predictor of post-concussion symptoms following mild TBI.",
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Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury : a systematic review. / Mercier, Eric; Tardif, Pier Alexandre; Cameron, Peter A.; Émond, Marcel; Moore, Lynne; Mitra, Biswadev; Ouellet, Marie Christine; Frenette, Jérôme; de Guise, Elaine; Le Sage, Natalie.

In: Brain Injury, Vol. 32, No. 1, 02.01.2018, p. 29-40.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury

T2 - a systematic review

AU - Mercier, Eric

AU - Tardif, Pier Alexandre

AU - Cameron, Peter A.

AU - Émond, Marcel

AU - Moore, Lynne

AU - Mitra, Biswadev

AU - Ouellet, Marie Christine

AU - Frenette, Jérôme

AU - de Guise, Elaine

AU - Le Sage, Natalie

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Background: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). Methods: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. Results: The search strategy yielded a total of 23,298 citations from which 8 cohorts presented in 10 studies were included. Studies included between 45 and 141 patients (total 608 patients). The outcomes most frequently assessed were post-concussion syndrome (PCS, 12 assessments) and neuropsychological performance deficits (10 assessments). No association was found between an elevated NSE serum level and PCS. Only one study reported a statistically significant association between a higher NSE serum level and alteration of at least three cognitive domains at 2 weeks but this association was no longer significant at 6 weeks. Overall, risk of bias of the included studies was considered moderate. Conclusions: Early NSE serum level is not a strong independent predictor of post-concussion symptoms following mild TBI.

AB - Background: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). Methods: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. Results: The search strategy yielded a total of 23,298 citations from which 8 cohorts presented in 10 studies were included. Studies included between 45 and 141 patients (total 608 patients). The outcomes most frequently assessed were post-concussion syndrome (PCS, 12 assessments) and neuropsychological performance deficits (10 assessments). No association was found between an elevated NSE serum level and PCS. Only one study reported a statistically significant association between a higher NSE serum level and alteration of at least three cognitive domains at 2 weeks but this association was no longer significant at 6 weeks. Overall, risk of bias of the included studies was considered moderate. Conclusions: Early NSE serum level is not a strong independent predictor of post-concussion symptoms following mild TBI.

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