TY - JOUR
T1 - Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer
AU - Salmena, Leonardo
AU - Shaw, Patricia A
AU - Fan, I
AU - McLaughlin, John R
AU - Rosen, Barry
AU - Risch, Harvey A
AU - Mitchell, Christina Anne
AU - Sun, P
AU - Narod, Steven A
AU - Kotsopoulos, Joanne
PY - 2015
Y1 - 2015
N2 - PURPOSE OF INVESTIGATION: Ovarian cancer is associated with poor prognosis and altered protein expression patterns may be useful for identifying patients likely to have poor disease outcomes. The impact of altered INPP4B protein expression on prognosis is unclear. The aim of this study was to evaluate the implication of INPP4B expression changes in a large series of ovarian cancer tissue samples. MATERIALS AND METHODS: Tissue microarrays were constructed from 599 epithelial ovarian tumors and stained with antibodies for INPP4B, p53, and PTEN. Proportional hazard models were used to estimate survival hazard ratios (HRs) associated with altered protein expression. RESULTS: Seventy-nine percent of the ovarian cancers demonstrated loss of INPP4B, whereas 53 showed aberrant p53 expression (i.e., complete loss of p53 or over-expression of p53) and 8 showed loss of PTEN. INPP4B was frequently lost in serous and endometrioid cancer subtypes, aberrant p53 expression was most common among serous subtype, and loss of PTEN was most common among endometrioid tumors (p for all three proteins across histologic subtypes
AB - PURPOSE OF INVESTIGATION: Ovarian cancer is associated with poor prognosis and altered protein expression patterns may be useful for identifying patients likely to have poor disease outcomes. The impact of altered INPP4B protein expression on prognosis is unclear. The aim of this study was to evaluate the implication of INPP4B expression changes in a large series of ovarian cancer tissue samples. MATERIALS AND METHODS: Tissue microarrays were constructed from 599 epithelial ovarian tumors and stained with antibodies for INPP4B, p53, and PTEN. Proportional hazard models were used to estimate survival hazard ratios (HRs) associated with altered protein expression. RESULTS: Seventy-nine percent of the ovarian cancers demonstrated loss of INPP4B, whereas 53 showed aberrant p53 expression (i.e., complete loss of p53 or over-expression of p53) and 8 showed loss of PTEN. INPP4B was frequently lost in serous and endometrioid cancer subtypes, aberrant p53 expression was most common among serous subtype, and loss of PTEN was most common among endometrioid tumors (p for all three proteins across histologic subtypes
UR - http://www.ncbi.nlm.nih.gov/pubmed/26189250
U2 - 10.12892/ejgo2741.2015
DO - 10.12892/ejgo2741.2015
M3 - Article
SN - 0392-2936
VL - 36
SP - 260
EP - 267
JO - European Journal of Gynaecological Oncology
JF - European Journal of Gynaecological Oncology
IS - 3
ER -
