Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

James Broadley; Robb Wesselingh; Udaya Seneviratne; Chris Kyndt; Paul Beech; Katherine Buzzard; Cassie Nesbitt; Wendyl D'souza; Amy Brodtmann; Richard Macdonell; Tomas Kalincik; Helmut Butzkueven; Terence J. O'Brien; Mastura Monif; on behalf of the Australian Autoimmune Encephalitis Consortium

doi:10.1016/j.jneuroim.2021.577508

Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

James Broadley, Robb Wesselingh, Udaya Seneviratne, Chris Kyndt, Paul Beech, Katherine Buzzard, Cassie Nesbitt, Wendyl D'souza, Amy Brodtmann, Richard Macdonell, Tomas Kalincik, Helmut Butzkueven, Terence J. O'Brien, Mastura Monif, on behalf of the Australian Autoimmune Encephalitis Consortium

Department of Neuroscience

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm³ and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm³ and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.

Original language	English
Article number	577508
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	353
DOIs	https://doi.org/10.1016/j.jneuroim.2021.577508
Publication status	Published - 15 Apr 2021

Keywords

Autoimmune encephalitis
Biomarker
CSF
Lymphocytosis
Prognosis

Access to Document

10.1016/j.jneuroim.2021.577508

Cite this

Broadley, J., Wesselingh, R., Seneviratne, U., Kyndt, C., Beech, P., Buzzard, K., Nesbitt, C., D'souza, W., Brodtmann, A., Macdonell, R., Kalincik, T., Butzkueven, H., O'Brien, T. J., Monif, M., & on behalf of the Australian Autoimmune Encephalitis Consortium (2021). Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis. Journal of Neuroimmunology, 353, Article 577508. https://doi.org/10.1016/j.jneuroim.2021.577508

@article{4eefa2b57bf54b47ae4a3f99af80f26e,

title = "Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis",

abstract = "Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm3 and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm3 and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.",

keywords = "Autoimmune encephalitis, Biomarker, CSF, Lymphocytosis, Prognosis",

author = "James Broadley and Robb Wesselingh and Udaya Seneviratne and Chris Kyndt and Paul Beech and Katherine Buzzard and Cassie Nesbitt and Wendyl D'souza and Amy Brodtmann and Richard Macdonell and Tomas Kalincik and Helmut Butzkueven and O'Brien, {Terence J.} and Mastura Monif and {on behalf of the Australian Autoimmune Encephalitis Consortium}",

year = "2021",

month = apr,

day = "15",

doi = "10.1016/j.jneuroim.2021.577508",

language = "English",

volume = "353",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier BV",

}

Broadley, J, Wesselingh, R , Seneviratne, U, Kyndt, C, Beech, P, Buzzard, K, Nesbitt, C, D'souza, W, Brodtmann, A, Macdonell, R, Kalincik, T, Butzkueven, H , O'Brien, TJ , Monif, M & on behalf of the Australian Autoimmune Encephalitis Consortium 2021, 'Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis', Journal of Neuroimmunology, vol. 353, 577508. https://doi.org/10.1016/j.jneuroim.2021.577508

TY - JOUR

T1 - Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

AU - Broadley, James

AU - Wesselingh, Robb

AU - Seneviratne, Udaya

AU - Kyndt, Chris

AU - Beech, Paul

AU - Buzzard, Katherine

AU - Nesbitt, Cassie

AU - D'souza, Wendyl

AU - Brodtmann, Amy

AU - Macdonell, Richard

AU - Kalincik, Tomas

AU - Butzkueven, Helmut

AU - O'Brien, Terence J.

AU - Monif, Mastura

AU - on behalf of the Australian Autoimmune Encephalitis Consortium

PY - 2021/4/15

Y1 - 2021/4/15

N2 - Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm3 and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm3 and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.

AB - Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm3 and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm3 and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.

KW - Autoimmune encephalitis

KW - Biomarker

KW - CSF

KW - Lymphocytosis

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=85100800554&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2021.577508

DO - 10.1016/j.jneuroim.2021.577508

M3 - Article

C2 - 33588218

AN - SCOPUS:85100800554

SN - 0165-5728

VL - 353

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577508

ER -

Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

Abstract

Keywords

Access to Document

Other files and links

Cite this