Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer

Heidi Fettke; Edmond M. Kwan; Patricia Bukczynska; Nicole Ng; Tu Nguyen-Dumont; Melissa C. Southey; Ian D. Davis; Andrew Mant; Phillip Parente; Carmel Pezaro; Christine Hauser; Arun A. Azad

doi:10.1016/j.euf.2020.07.001

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer

Heidi Fettke, Edmond M. Kwan, Patricia Bukczynska, Nicole Ng, Tu Nguyen-Dumont, Melissa C. Southey, Ian D. Davis, Andrew Mant, Phillip Parente, Carmel Pezaro, Christine Hauser, Arun A. Azad

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

A higher total cell-free DNA (cfDNA) level is a poor prognosticator in advanced prostate cancer patients receiving novel hormonal therapies. Additionally, an early on-treatment rise in cfDNA levels predicts for better outcomes. Therefore, total cfDNA concentration may assist in prognostication and predicting treatment outcome.

Original language	English
Pages (from-to)	1287-1291
Number of pages	5
Journal	European Urology Focus
DOIs	https://doi.org/10.1016/j.euf.2020.07.001
Publication status	Published - Nov 2021

Keywords

Abiraterone
Androgen receptor pathway inhibitor
Biomarker
Castrate resistant
Cell-free DNA
Enzalutamide
Liquid biopsy
Prostate cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.euf.2020.07.001

Cite this

Fettke, H., Kwan, E. M., Bukczynska, P., Ng, N., Nguyen-Dumont, T., Southey, M. C., Davis, I. D., Mant, A., Parente, P., Pezaro, C., Hauser, C., & Azad, A. A. (2021). Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer. European Urology Focus, 1287-1291. https://doi.org/10.1016/j.euf.2020.07.001

Fettke, Heidi ; Kwan, Edmond M. ; Bukczynska, Patricia ; Ng, Nicole ; Nguyen-Dumont, Tu ; Southey, Melissa C. ; Davis, Ian D. ; Mant, Andrew ; Parente, Phillip ; Pezaro, Carmel ; Hauser, Christine ; Azad, Arun A. / Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer. In: European Urology Focus. 2021 ; pp. 1287-1291.

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title = "Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer",

abstract = "A higher total cell-free DNA (cfDNA) level is a poor prognosticator in advanced prostate cancer patients receiving novel hormonal therapies. Additionally, an early on-treatment rise in cfDNA levels predicts for better outcomes. Therefore, total cfDNA concentration may assist in prognostication and predicting treatment outcome.",

keywords = "Abiraterone, Androgen receptor pathway inhibitor, Biomarker, Castrate resistant, Cell-free DNA, Enzalutamide, Liquid biopsy, Prostate cancer",

author = "Heidi Fettke and Kwan, {Edmond M.} and Patricia Bukczynska and Nicole Ng and Tu Nguyen-Dumont and Southey, {Melissa C.} and Davis, {Ian D.} and Andrew Mant and Phillip Parente and Carmel Pezaro and Christine Hauser and Azad, {Arun A.}",

year = "2021",

month = nov,

doi = "10.1016/j.euf.2020.07.001",

language = "English",

pages = "1287--1291",

journal = "European Urology Focus",

issn = "2405-4569",

publisher = "Elsevier BV",

}

Fettke, H, Kwan, EM, Bukczynska, P, Ng, N, Nguyen-Dumont, T , Southey, MC , Davis, ID, Mant, A, Parente, P, Pezaro, C, Hauser, C & Azad, AA 2021, 'Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer', European Urology Focus, pp. 1287-1291. https://doi.org/10.1016/j.euf.2020.07.001

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer. / Fettke, Heidi; Kwan, Edmond M.; Bukczynska, Patricia; Ng, Nicole; Nguyen-Dumont, Tu ; Southey, Melissa C.; Davis, Ian D.; Mant, Andrew; Parente, Phillip; Pezaro, Carmel; Hauser, Christine; Azad, Arun A.

In: European Urology Focus, 11.2021, p. 1287-1291.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer

AU - Fettke, Heidi

AU - Kwan, Edmond M.

AU - Bukczynska, Patricia

AU - Ng, Nicole

AU - Nguyen-Dumont, Tu

AU - Southey, Melissa C.

AU - Davis, Ian D.

AU - Mant, Andrew

AU - Parente, Phillip

AU - Pezaro, Carmel

AU - Hauser, Christine

AU - Azad, Arun A.

PY - 2021/11

Y1 - 2021/11

N2 - A higher total cell-free DNA (cfDNA) level is a poor prognosticator in advanced prostate cancer patients receiving novel hormonal therapies. Additionally, an early on-treatment rise in cfDNA levels predicts for better outcomes. Therefore, total cfDNA concentration may assist in prognostication and predicting treatment outcome.

AB - A higher total cell-free DNA (cfDNA) level is a poor prognosticator in advanced prostate cancer patients receiving novel hormonal therapies. Additionally, an early on-treatment rise in cfDNA levels predicts for better outcomes. Therefore, total cfDNA concentration may assist in prognostication and predicting treatment outcome.

KW - Abiraterone

KW - Androgen receptor pathway inhibitor

KW - Biomarker

KW - Castrate resistant

KW - Cell-free DNA

KW - Enzalutamide

KW - Liquid biopsy

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85089008818&partnerID=8YFLogxK

U2 - 10.1016/j.euf.2020.07.001

DO - 10.1016/j.euf.2020.07.001

M3 - Article

C2 - 32739405

AN - SCOPUS:85089008818

SP - 1287

EP - 1291

JO - European Urology Focus

JF - European Urology Focus

SN - 2405-4569

ER -

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Precision Medicine for Prostate and Breast Cancer

Profiling circulating DNA and RNA to identify mechanisms of therapeutic resistance and response in metastatic castration-resistant prostate cancer

NHMRC Practitioner Fellowship

Cite this

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor–treated Metastatic Castration-resistant Prostate Cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Precision Medicine for Prostate and Breast Cancer

Profiling circulating DNA and RNA to identify mechanisms of therapeutic resistance and response in metastatic castration-resistant prostate cancer

NHMRC Practitioner Fellowship

Cite this