Profluorescent nitroxides as sensitive probes of oxidative change and free radical reactions

James P Blinco, Kathryn E Fairfull-Smith, Benjamin Joseph Morrow, Steven Eric Bottle

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93 Citations (Scopus)


This paper presents a review on the use of tethered nitroxidefluorophore molecules as probes of oxidative change and free radical generation and reaction. The proximity of the nitroxide free radical to the fluorophore suppresses the normal fluorescence emission process. Nitroxide free radical scavenging, metabolism or redox chemistry return the system to its natural fluorescent state and so these tethered nitroxidefluorophore molecules are described as being profluorescent. A survey of profluorescent nitroxides found in the literature is provided as well as background on the mechanism of action and applications of these compounds as fluorometric probes within the fields of biological, materials and environmental sciences.
Original languageEnglish
Pages (from-to)373 - 389
Number of pages17
JournalAustralian Journal of Chemistry
Issue number4
Publication statusPublished - 2011
Externally publishedYes

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