Profiling clinical platelet and plasma use to inform blood supply and contingency planning: PUPPY, the prospective utilization of platelets and plasma study

Pasquale L. Fedele, Mark N. Polizzotto, George Grigoriadis, Neil Waters, Mary Comande, Marija Borosak, David Portbury, Erica M. Wood

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND
Demand for platelet (PLT) and plasma transfusions is increasing. Improved clinical supply and contingency planning requires greater understanding of usage profiles and urgency of clinical requirement.
STUDY DESIGN AND METHODS
This study was a random-sample survey of PLT and plasma units produced in Victoria, Australia, to determine product disposition, recipient demographics, clinical indications for transfusion, and urgency (or “deferability”) of need. PLTs and fresh-frozen plasma (FFP) were tagged with a case report form before distribution.
RESULTS
A total of 1252 PLT and 1837 FFP units were tagged, comprising 8.3 and 13.3% of all products issued during the study period. The fate of 1243 PLT and 1808 FFP units was determined. Of products issued, 72.2% of PLTs and 87.8% of FFP were transfused. Hematologic and oncologic disorders accounted for 63.9% of PLT transfusions, with acute myeloid leukemia alone accounting for 26%. Conversely, surgical patients received the largest proportion of FFP (40.4%), predominantly for cardiothoracic, solid organ transplant, and vascular surgery. Approximately 15% of PLT transfusions and 35% of plasma transfusions were required within 1 hour, and 80% of PLT transfusions and 90% of FFP transfusions were required within 24 hours. Wastage rates were higher in regional blood banks.
CONCLUSION
The PUPPY study is a comprehensive and detailed population-based assessment of PLT and plasma usage, including urgency of use. It identifies specific clinical areas with high demand for PLT and FFP transfusion and demonstrates the high urgency of need for both products. These data inform clinical supply and contingency planning activities.
Original languageEnglish
Pages (from-to)2455-2465
Number of pages11
JournalTransfusion
Volume56
DOIs
Publication statusPublished - Oct 2016

Cite this

@article{59051ab9640a4b68a55f736c2398b3ba,
title = "Profiling clinical platelet and plasma use to inform blood supply and contingency planning: PUPPY, the prospective utilization of platelets and plasma study",
abstract = "BACKGROUNDDemand for platelet (PLT) and plasma transfusions is increasing. Improved clinical supply and contingency planning requires greater understanding of usage profiles and urgency of clinical requirement.STUDY DESIGN AND METHODSThis study was a random-sample survey of PLT and plasma units produced in Victoria, Australia, to determine product disposition, recipient demographics, clinical indications for transfusion, and urgency (or “deferability”) of need. PLTs and fresh-frozen plasma (FFP) were tagged with a case report form before distribution.RESULTSA total of 1252 PLT and 1837 FFP units were tagged, comprising 8.3 and 13.3{\%} of all products issued during the study period. The fate of 1243 PLT and 1808 FFP units was determined. Of products issued, 72.2{\%} of PLTs and 87.8{\%} of FFP were transfused. Hematologic and oncologic disorders accounted for 63.9{\%} of PLT transfusions, with acute myeloid leukemia alone accounting for 26{\%}. Conversely, surgical patients received the largest proportion of FFP (40.4{\%}), predominantly for cardiothoracic, solid organ transplant, and vascular surgery. Approximately 15{\%} of PLT transfusions and 35{\%} of plasma transfusions were required within 1 hour, and 80{\%} of PLT transfusions and 90{\%} of FFP transfusions were required within 24 hours. Wastage rates were higher in regional blood banks.CONCLUSIONThe PUPPY study is a comprehensive and detailed population-based assessment of PLT and plasma usage, including urgency of use. It identifies specific clinical areas with high demand for PLT and FFP transfusion and demonstrates the high urgency of need for both products. These data inform clinical supply and contingency planning activities.",
author = "Fedele, {Pasquale L.} and Polizzotto, {Mark N.} and George Grigoriadis and Neil Waters and Mary Comande and Marija Borosak and David Portbury and Wood, {Erica M.}",
year = "2016",
month = "10",
doi = "10.1111/trf.13778",
language = "English",
volume = "56",
pages = "2455--2465",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",

}

Profiling clinical platelet and plasma use to inform blood supply and contingency planning : PUPPY, the prospective utilization of platelets and plasma study. / Fedele, Pasquale L.; Polizzotto, Mark N.; Grigoriadis, George; Waters, Neil; Comande, Mary; Borosak, Marija; Portbury, David; Wood, Erica M.

In: Transfusion, Vol. 56, 10.2016, p. 2455-2465.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Profiling clinical platelet and plasma use to inform blood supply and contingency planning

T2 - PUPPY, the prospective utilization of platelets and plasma study

AU - Fedele, Pasquale L.

AU - Polizzotto, Mark N.

AU - Grigoriadis, George

AU - Waters, Neil

AU - Comande, Mary

AU - Borosak, Marija

AU - Portbury, David

AU - Wood, Erica M.

PY - 2016/10

Y1 - 2016/10

N2 - BACKGROUNDDemand for platelet (PLT) and plasma transfusions is increasing. Improved clinical supply and contingency planning requires greater understanding of usage profiles and urgency of clinical requirement.STUDY DESIGN AND METHODSThis study was a random-sample survey of PLT and plasma units produced in Victoria, Australia, to determine product disposition, recipient demographics, clinical indications for transfusion, and urgency (or “deferability”) of need. PLTs and fresh-frozen plasma (FFP) were tagged with a case report form before distribution.RESULTSA total of 1252 PLT and 1837 FFP units were tagged, comprising 8.3 and 13.3% of all products issued during the study period. The fate of 1243 PLT and 1808 FFP units was determined. Of products issued, 72.2% of PLTs and 87.8% of FFP were transfused. Hematologic and oncologic disorders accounted for 63.9% of PLT transfusions, with acute myeloid leukemia alone accounting for 26%. Conversely, surgical patients received the largest proportion of FFP (40.4%), predominantly for cardiothoracic, solid organ transplant, and vascular surgery. Approximately 15% of PLT transfusions and 35% of plasma transfusions were required within 1 hour, and 80% of PLT transfusions and 90% of FFP transfusions were required within 24 hours. Wastage rates were higher in regional blood banks.CONCLUSIONThe PUPPY study is a comprehensive and detailed population-based assessment of PLT and plasma usage, including urgency of use. It identifies specific clinical areas with high demand for PLT and FFP transfusion and demonstrates the high urgency of need for both products. These data inform clinical supply and contingency planning activities.

AB - BACKGROUNDDemand for platelet (PLT) and plasma transfusions is increasing. Improved clinical supply and contingency planning requires greater understanding of usage profiles and urgency of clinical requirement.STUDY DESIGN AND METHODSThis study was a random-sample survey of PLT and plasma units produced in Victoria, Australia, to determine product disposition, recipient demographics, clinical indications for transfusion, and urgency (or “deferability”) of need. PLTs and fresh-frozen plasma (FFP) were tagged with a case report form before distribution.RESULTSA total of 1252 PLT and 1837 FFP units were tagged, comprising 8.3 and 13.3% of all products issued during the study period. The fate of 1243 PLT and 1808 FFP units was determined. Of products issued, 72.2% of PLTs and 87.8% of FFP were transfused. Hematologic and oncologic disorders accounted for 63.9% of PLT transfusions, with acute myeloid leukemia alone accounting for 26%. Conversely, surgical patients received the largest proportion of FFP (40.4%), predominantly for cardiothoracic, solid organ transplant, and vascular surgery. Approximately 15% of PLT transfusions and 35% of plasma transfusions were required within 1 hour, and 80% of PLT transfusions and 90% of FFP transfusions were required within 24 hours. Wastage rates were higher in regional blood banks.CONCLUSIONThe PUPPY study is a comprehensive and detailed population-based assessment of PLT and plasma usage, including urgency of use. It identifies specific clinical areas with high demand for PLT and FFP transfusion and demonstrates the high urgency of need for both products. These data inform clinical supply and contingency planning activities.

U2 - 10.1111/trf.13778

DO - 10.1111/trf.13778

M3 - Article

VL - 56

SP - 2455

EP - 2465

JO - Transfusion

JF - Transfusion

SN - 0041-1132

ER -