Products of cytochrome P450Biol (CYP107H1)-catalyzed oxidation of fatty acids

Max J. Cryle, Nick J. Matovic, James J. de Voss

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Abstract

(Matrix presented) Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450Biol (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C14 fatty acids and the 11- to 15-hydroxy C16 fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450Biol was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.

Original languageEnglish
Pages (from-to)3341-3344
Number of pages4
JournalOrganic Letters
Volume5
Issue number18
DOIs
Publication statusPublished - 4 Sep 2003
Externally publishedYes

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