Problems and advantages of continuous renal replacement therapy

Merlin C. Thomas, David C.H. Harris

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)


The continuous replacement of renal function must facilitate fluid and solute homeostasis, nutrition and vital organ function, and, where possible, hasten the recovery of renal function. Difficulties with anticoagulation, biocompatibility, mobility and cost remain obstacles to be overcome. The use of continuous renal replacement therapy (CRRT) to remove systemic inflammatory mediators is yet to be confirmed. Although survival benefits of CRRT over intermittent dialysis remain controversial, the slow continuous removal of fluid, acid and solute has a number of advantages, especially where patients are haemodynamically unstable.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
Issue number3
Publication statusPublished - 23 Sep 2002
Externally publishedYes


  • Acute renal failure
  • Continuous renal replacement therapy
  • Haemofiltration
  • Heamodialysis
  • Ultrafiltration

Cite this