TY - JOUR
T1 - Probiotic yogurt improves body mass index and fasting insulin levels without affecting serum leptin and adiponectin levels in non-alcoholic fatty liver disease (NAFLD)
AU - Nabavi, Safoora
AU - Rafraf, Maryam
AU - Somi, Mohammad hossein
AU - Homayouni-Rad, Aziz
AU - Asghari-Jafarabadi, Mohammad
N1 - Funding Information:
We thank the Research Vice-Chancellor and Nutrition Research Center of Tabriz University of Medical Sciences , Tabriz, Iran, for the financial support, Pegah Dairy Industries Co. (Tabriz, Iran) for supplying the probiotic and conventional yogurts, and the patients who participated in this study. This article is based on data obtained from MSc. Thesis which was done in Tabriz University of Medical Sciences.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - There is evidence of possible beneficial effects of probiotic products in non-alcoholic fatty liver disease (NAFLD). Here the effects of probiotic yogurt consumption on obesity values, fasting insulin, insulin resistance, and serum leptin and adiponectin levels in NAFLD patients were investigated by a randomized double-blind controlled clinical trial. Seventy-two subjects, aged between 23 and 63 years, were divided into two groups. Subjects consumed either 300g/day of probiotic yogurt or 300g/day of conventional yogurt for 8weeks. Probiotic yogurt consumption resulted in a significant reduction in weight, body mass index, and serum levels of fasting insulin as compared with that in the control group. No significant changes were observed in waist circumference, homeostasis model assessment insulin resistance, serum leptin, adiponectin, and leptin to adiponectin ratio in both groups. Our study suggests that probiotic yogurt consumption improved body mass index and insulin levels and may be applicable in reducing risk factors of NAFLD.
AB - There is evidence of possible beneficial effects of probiotic products in non-alcoholic fatty liver disease (NAFLD). Here the effects of probiotic yogurt consumption on obesity values, fasting insulin, insulin resistance, and serum leptin and adiponectin levels in NAFLD patients were investigated by a randomized double-blind controlled clinical trial. Seventy-two subjects, aged between 23 and 63 years, were divided into two groups. Subjects consumed either 300g/day of probiotic yogurt or 300g/day of conventional yogurt for 8weeks. Probiotic yogurt consumption resulted in a significant reduction in weight, body mass index, and serum levels of fasting insulin as compared with that in the control group. No significant changes were observed in waist circumference, homeostasis model assessment insulin resistance, serum leptin, adiponectin, and leptin to adiponectin ratio in both groups. Our study suggests that probiotic yogurt consumption improved body mass index and insulin levels and may be applicable in reducing risk factors of NAFLD.
KW - Adiponectin
KW - Insulin
KW - Leptin
KW - Non-alcoholic fatty liver disease
KW - Obesity values
KW - Probiotic yogurt
UR - http://www.scopus.com/inward/record.url?scp=84942516437&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2015.08.031
DO - 10.1016/j.jff.2015.08.031
M3 - Article
AN - SCOPUS:84942516437
SN - 1756-4646
VL - 18
SP - 684
EP - 691
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 1279
ER -