Low-energy experiments involving kaon, B-meson, D-meson, and hyperon flavor-changing neutral transitions have confirmed the loop-induced flavor-changing neutral current picture of the standard model. The continuing study of these processes is essential to further refine this picture and ultimately understand the flavor dynamics. In this paper we consider deviations from the standard model in the charm sector and their effect on flavor-changing neutral current processes. Specifically, we parametrize new physics in terms of left- and right-handed anomalous couplings of the W boson to the charm quark. We present a comprehensive study of existing constraints and point out those measurements that are most sensitive to new physics of this type.