Probing bacterial-toxin inhibition with synthetic glycopolymers prepared by tandem post-polymerization modification: Role of linker length and carbohydrate density

Sarah Jane Richards, Mathew W. Jones, Mark Hunaban, David M. Haddleton, Matthew I. Gibson

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

Abstract

Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.

Original languageEnglish
Pages (from-to)7812-7816
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number31
DOIs
Publication statusPublished - 27 Jul 2012
Externally publishedYes

Keywords

  • bioorganic polymers
  • carbohydrates
  • cholera toxin
  • click chemistry
  • glycoconjugates

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