Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

John Wentworth, Gaetano Naselli, Wendy Brown, Lisa Doyle, Belinda Phipson, Gordon Smyth, Martin Wabitsch, Paul O'Brien, Leonard Harrison

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    491 Citations (Scopus)

    Abstract

    Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.
    Original languageEnglish
    Pages (from-to)1648 - 1656
    Number of pages9
    JournalDiabetes
    Volume59
    Issue number7
    DOIs
    Publication statusPublished - 2010

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