Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

John Wentworth, Gaetano Naselli, Wendy Brown, Lisa Doyle, Belinda Phipson, Gordon Smyth, Martin Wabitsch, Paul O'Brien, Leonard Harrison

Research output: Contribution to journalArticleResearchpeer-review

350 Citations (Scopus)

Abstract

Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.
Original languageEnglish
Pages (from-to)1648 - 1656
Number of pages9
JournalDiabetes
Volume59
Issue number7
DOIs
Publication statusPublished - 2010

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