Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

John Wentworth; Gaetano Naselli; Wendy Brown; Lisa Doyle; Belinda Phipson; Gordon Smyth; Martin Wabitsch; Paul O'Brien; Leonard Harrison

doi:10.2337/db09-0287

Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

John Wentworth, Gaetano Naselli, Wendy Brown, Lisa Doyle, Belinda Phipson, Gordon Smyth, Martin Wabitsch, Paul O'Brien, Leonard Harrison

Centre for Obesity Research and Education

Research output: Contribution to journal › Article › Research › peer-review

434 Citations (Scopus)

Abstract

Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.

Original language	English
Pages (from-to)	1648 - 1656
Number of pages	9
Journal	Diabetes
Volume	59
Issue number	7
DOIs	https://doi.org/10.2337/db09-0287
Publication status	Published - 2010

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10.2337/db09-0287

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@article{58a4ed02956948d6a3464ad9280a3301,

title = "Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity",

abstract = "Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.",

author = "John Wentworth and Gaetano Naselli and Wendy Brown and Lisa Doyle and Belinda Phipson and Gordon Smyth and Martin Wabitsch and Paul O'Brien and Leonard Harrison",

year = "2010",

doi = "10.2337/db09-0287",

language = "English",

volume = "59",

pages = "1648 -- 1656",

journal = "Diabetes",

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T1 - Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

AU - Wentworth, John

AU - Naselli, Gaetano

AU - Brown, Wendy

AU - Doyle, Lisa

AU - Phipson, Belinda

AU - Smyth, Gordon

AU - Wabitsch, Martin

AU - O'Brien, Paul

AU - Harrison, Leonard

PY - 2010

Y1 - 2010

N2 - Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.

AB - Objective: Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity.

UR - http://www.ncbi.nlm.nih.gov/pubmed/20357360

U2 - 10.2337/db09-0287

DO - 10.2337/db09-0287

M3 - Article

VL - 59

SP - 1648

EP - 1656

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -

Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

Abstract

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