TY - JOUR
T1 - Principles of T2∗-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging
AU - Shiroishi, Mark S.
AU - Castellazzi, Gloria
AU - Boxerman, Jerrold L.
AU - D'Amore, Francesco
AU - Essig, Marco
AU - Nguyen, Thanh B.
AU - Provenzale, James M.
AU - Enterline, David S.
AU - Anzalone, Nicoletta
AU - Dörfler, Arnd
AU - Rovira, Àlex
AU - Wintermark, Max
AU - Law, Meng
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor hemodynamics. DSC-MRI parameters can be helpful in many aspects, including tumor grading, prediction of treatment response, likelihood of malignant transformation, discrimination between tumor recurrence and radiation necrosis, and differentiation between true early progression and pseudoprogression. This review aims to provide a conceptual overview of the underlying principles of DSC-MRI of the brain for clinical neuroradiologists, scientists, or students wishing to improve their understanding of the technical aspects, pitfalls, and controversies of DSC perfusion MRI of the brain. Future consensus on image acquisition parameters and postprocessing of DSC-MRI will most likely allow this technique to be evaluated and used in high-quality multicenter studies and ultimately help guide clinical care.
AB - Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor hemodynamics. DSC-MRI parameters can be helpful in many aspects, including tumor grading, prediction of treatment response, likelihood of malignant transformation, discrimination between tumor recurrence and radiation necrosis, and differentiation between true early progression and pseudoprogression. This review aims to provide a conceptual overview of the underlying principles of DSC-MRI of the brain for clinical neuroradiologists, scientists, or students wishing to improve their understanding of the technical aspects, pitfalls, and controversies of DSC perfusion MRI of the brain. Future consensus on image acquisition parameters and postprocessing of DSC-MRI will most likely allow this technique to be evaluated and used in high-quality multicenter studies and ultimately help guide clinical care.
KW - Brain tumors
KW - Cerebral blood volume
KW - Echo planar imaging
KW - Gadolinium-based contrast agents
KW - Perfusion magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84921731674&partnerID=8YFLogxK
U2 - 10.1002/jmri.24648
DO - 10.1002/jmri.24648
M3 - Review Article
C2 - 24817252
AN - SCOPUS:84921731674
SN - 1053-1807
VL - 41
SP - 296
EP - 313
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 2
ER -