Principles and applications of comprehensive two-dimensional gas chromatography

Philip Marriott, Robert Shellie

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253 Citations (Scopus)


This issue of Trends in Analytical Chemistry celebrates 50 years of gas chromatography (GC) - the greatest enabling technology for chemical analysis of volatile compounds. However, what may be considered the most powerful separation tool in GC - comprehensive two-dimensional gas chromatography (GC×GC) - is a development born of the 1990s. It was first described and almost fully established in the last decade of the twentieth century. The coming decades can be expected to see it flourish into a major operating mode of GC, when applications and fundamental principles will be further expanded, and, most importantly, its universal acceptance will be unquestioned. This article describes why the pioneers of GC×GC have so much faith in the new opportunities afforded by this exciting technology.

Original languageEnglish
Pages (from-to)573-583
Number of pages11
JournalTrAC - Trends in Analytical Chemistry
Issue number9-10
Publication statusPublished - 1 Jan 2002
Externally publishedYes


  • Comprehensive two-dimensional gas chromatography
  • GC×GC
  • High resolution
  • Modulation
  • Multi-dimensional gas chromatography
  • Orthogonal separation

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