Prevention of ovarian hyperstimulation syndrome: a review

Vinayak Smith, Tiki Osianlis, Beverley Janine Vollenhoven

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Mullerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a step-up regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalObstetrics and Gynecology International
Volume2015
DOIs
Publication statusPublished - 2015

Cite this

Smith, Vinayak ; Osianlis, Tiki ; Vollenhoven, Beverley Janine. / Prevention of ovarian hyperstimulation syndrome: a review. In: Obstetrics and Gynecology International. 2015 ; Vol. 2015. pp. 1 - 10.
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Smith, V, Osianlis, T & Vollenhoven, BJ 2015, 'Prevention of ovarian hyperstimulation syndrome: a review', Obstetrics and Gynecology International, vol. 2015, pp. 1 - 10. https://doi.org/10.1155/2015/514159

Prevention of ovarian hyperstimulation syndrome: a review. / Smith, Vinayak; Osianlis, Tiki; Vollenhoven, Beverley Janine.

In: Obstetrics and Gynecology International, Vol. 2015, 2015, p. 1 - 10.

Research output: Contribution to journal › Article › Research › peer-review

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AB - The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Mullerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a step-up regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.

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Smith V, Osianlis T, Vollenhoven BJ. Prevention of ovarian hyperstimulation syndrome: a review. Obstetrics and Gynecology International. 2015;2015:1 - 10. https://doi.org/10.1155/2015/514159

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