Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: current standards of care

Michelle Leanne Giles, Ruth Grace, Amy Tai, Katarzyna Michalak, Susan Walker

Research output: Contribution to journalArticleOther

18 Citations (Scopus)

Abstract

Background Mother-to-child transmission (MTCT) of hepatitis B virus continues to occur despite the interventions of hepatitis B vaccination and immunoglobulin. The most significant risk factor in transmission is high maternal viral load. Being aware of viral replicative activity permits risk stratification and allows the opportunity for additional preventative measures such as antiviral therapy. Methods Retrospective audit of investigations and clinical management among hepatitis B surface antigen-positive pregnant women from three maternity services across Victoria over a five-year period from 2006 to 2011. Results Over the study period at the three institutions, there were 46,855 births, and 398 hepatitis B-positive pregnant women. 87 of the women were non-Australian-born. Viral load testing was performed in 90 ). Conclusion There is scope for considerable improvement in referral and assessment of pregnant women with hepatitis B infection. Guidelines addressing the issue of maternal viral replicative status and the need for antiviral therapy may assist in guiding clinical management. ? 2013 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Original languageEnglish
Pages (from-to)231 - 235
Number of pages5
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Volume53
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

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title = "Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: current standards of care",
abstract = "Background Mother-to-child transmission (MTCT) of hepatitis B virus continues to occur despite the interventions of hepatitis B vaccination and immunoglobulin. The most significant risk factor in transmission is high maternal viral load. Being aware of viral replicative activity permits risk stratification and allows the opportunity for additional preventative measures such as antiviral therapy. Methods Retrospective audit of investigations and clinical management among hepatitis B surface antigen-positive pregnant women from three maternity services across Victoria over a five-year period from 2006 to 2011. Results Over the study period at the three institutions, there were 46,855 births, and 398 hepatitis B-positive pregnant women. 87 of the women were non-Australian-born. Viral load testing was performed in 90 ). Conclusion There is scope for considerable improvement in referral and assessment of pregnant women with hepatitis B infection. Guidelines addressing the issue of maternal viral replicative status and the need for antiviral therapy may assist in guiding clinical management. ? 2013 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.",
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Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: current standards of care. / Giles, Michelle Leanne; Grace, Ruth; Tai, Amy; Michalak, Katarzyna; Walker, Susan.

In: Australian and New Zealand Journal of Obstetrics and Gynaecology, Vol. 53, No. 3, 2013, p. 231 - 235.

Research output: Contribution to journalArticleOther

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T1 - Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: current standards of care

AU - Giles, Michelle Leanne

AU - Grace, Ruth

AU - Tai, Amy

AU - Michalak, Katarzyna

AU - Walker, Susan

PY - 2013

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N2 - Background Mother-to-child transmission (MTCT) of hepatitis B virus continues to occur despite the interventions of hepatitis B vaccination and immunoglobulin. The most significant risk factor in transmission is high maternal viral load. Being aware of viral replicative activity permits risk stratification and allows the opportunity for additional preventative measures such as antiviral therapy. Methods Retrospective audit of investigations and clinical management among hepatitis B surface antigen-positive pregnant women from three maternity services across Victoria over a five-year period from 2006 to 2011. Results Over the study period at the three institutions, there were 46,855 births, and 398 hepatitis B-positive pregnant women. 87 of the women were non-Australian-born. Viral load testing was performed in 90 ). Conclusion There is scope for considerable improvement in referral and assessment of pregnant women with hepatitis B infection. Guidelines addressing the issue of maternal viral replicative status and the need for antiviral therapy may assist in guiding clinical management. ? 2013 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

AB - Background Mother-to-child transmission (MTCT) of hepatitis B virus continues to occur despite the interventions of hepatitis B vaccination and immunoglobulin. The most significant risk factor in transmission is high maternal viral load. Being aware of viral replicative activity permits risk stratification and allows the opportunity for additional preventative measures such as antiviral therapy. Methods Retrospective audit of investigations and clinical management among hepatitis B surface antigen-positive pregnant women from three maternity services across Victoria over a five-year period from 2006 to 2011. Results Over the study period at the three institutions, there were 46,855 births, and 398 hepatitis B-positive pregnant women. 87 of the women were non-Australian-born. Viral load testing was performed in 90 ). Conclusion There is scope for considerable improvement in referral and assessment of pregnant women with hepatitis B infection. Guidelines addressing the issue of maternal viral replicative status and the need for antiviral therapy may assist in guiding clinical management. ? 2013 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

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