Prevention of diabetes and reduction in major cardiovascular events in studies of subjects with prediabetes: Meta-analysis of randomised controlled clinical trials

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Abstract Background: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are pre-diabetic states, treatment of which may prevent or delay the onset of overt diabetes and thus potentially reduce major cardiovascular (CV) events. We therefore sought to determine whether interventions (including diet, exercise and pharmacological therapy), altered all-cause and cardiovascular related mortality in such subjects. Methods: We performed a meta-analysis of prospective, randomised controlled trials (RCTs) that were identified in the medical literature and databases. Trials were eligible for inclusion if they reported all-cause mortality rates (at a minimum), recruited approximately 100 patients and had a minimum follow-up of one year. Interventions were divided into pharmacological and non-pharmacological. Results: Ten RCTs that enrolled 23,152 patients met the above entry criteria. Trials ran for an average of 3.75 years. Diabetes was delayed or prevented by these interventions vs control (risk ratio 0.83, 95 CI 0.80a??0.86). Non-drug approaches (nA?3495) were superior to drug-based approaches (nA?20,872) in diabetes prevention (0.52, 0.46a??0.58 vs 0.70, 0.58a??0.85, P
Original languageEnglish
Pages (from-to)813 - 823
Number of pages11
JournalEuropean Journal of Cardiovascular Prevention & Rehabilitation
Issue number6
Publication statusPublished - 2011

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