Prevention of awareness during anaesthesia

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Inadequate anaesthesia may lead to awareness. A properly trained anaesthetist, administering anaesthesia according to their knowledge of pharmacology and patient and surgical characteristics, assisted by clinical signs and monitoring, can minimize this risk. Relying upon volatile-based anaesthesia delivered at a concentration of at least 0.5 MAC may be effective, but this precludes the use of total intravenous anaesthesia techniques and in any case may lead to unwanted hypotension. Equipment failure may occur. Benzodiazepines do not protect the patient from awareness. The development of electroencephalographic monitors of anaesthetic depth provides an opportunity to prevent awareness. Two large scale studies, one of which was a randomized trial, have identified a 5-fold reduction in risk of awareness when depth of anaesthesia using bispectral index monitoring was used. The incidence of awareness can be further reduced with currently available techniques used more widely.

Original languageEnglish
Pages (from-to)345-355
Number of pages11
JournalBailliere's Best Practice and Research in Clinical Anaesthesiology
Volume21
Issue number3
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

Keywords

  • bispectral index
  • clinical trials
  • entropy
  • evidence
  • evoked potentials
  • monitoring
  • patient safety

Cite this

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title = "Prevention of awareness during anaesthesia",
abstract = "Inadequate anaesthesia may lead to awareness. A properly trained anaesthetist, administering anaesthesia according to their knowledge of pharmacology and patient and surgical characteristics, assisted by clinical signs and monitoring, can minimize this risk. Relying upon volatile-based anaesthesia delivered at a concentration of at least 0.5 MAC may be effective, but this precludes the use of total intravenous anaesthesia techniques and in any case may lead to unwanted hypotension. Equipment failure may occur. Benzodiazepines do not protect the patient from awareness. The development of electroencephalographic monitors of anaesthetic depth provides an opportunity to prevent awareness. Two large scale studies, one of which was a randomized trial, have identified a 5-fold reduction in risk of awareness when depth of anaesthesia using bispectral index monitoring was used. The incidence of awareness can be further reduced with currently available techniques used more widely.",
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Prevention of awareness during anaesthesia. / Myles, Paul S.

In: Bailliere's Best Practice and Research in Clinical Anaesthesiology, Vol. 21, No. 3, 09.2007, p. 345-355.

Research output: Contribution to journalReview ArticleResearchpeer-review

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