Adverse effects are a major deterrent to successful treatment with antiepileptic drugs (AEDs). Adverse effects can be classified in different ways. Using a modified version of the World Health Organization (WHO) classification, adverse effects of AEDs can be distinguished into five types: type A (acute, related to known mechanism of action of the drug); type B (idiosyncratic); type C (chronic); type D (delayed); and type E (secondary to drug interactions). This chapter discusses the effects of types A, B and C. Before prescribing a drug, the adverse effect profile should be tailored to the characteristics of the individual patient. For prevention measures to be effective, a therapeutic alliance between the clinician and the patient is necessary. The chapter also talks about medical and psychiatric comorbidities, central nervous system (CNS) dose‐dependent adverse effects, titration rates, and serum drug concentrations.
|Title of host publication||The Treatment of Epilepsy|
|Editors||Simon Shorvon, Emilio Perucca, Jerome Engel, Jr.|
|Place of Publication||UK|
|Number of pages||13|
|Publication status||Published - 2016|
Zaccara, G., & Perucca, P. C. (2016). Prevention and Management of Side‐effects of Antiepileptic Drugs. In S. Shorvon, E. Perucca, & J. Engel, Jr. (Eds.), The Treatment of Epilepsy (Fourth ed., pp. 275-287). Wiley-Blackwell. https://doi.org/10.1002/9781118936979.ch20