TY - JOUR
T1 - Preventing insulin dependent diabetes mellitus
T2 - The environmental challenge
AU - LaPorte, Ronald E.
AU - Dorman, Janice S.
AU - Orchard, Trevor J.
AU - Becker, Dorothy J.
AU - Drash, Allan L.
AU - Tajima, Naoko
AU - Ekoe, Jean Marie
AU - Tuomilehto, Jaakko
AU - Rewers, Marian
AU - Zimmet, Paul
AU - Karp, Moshe
AU - Mohan, Viswanathan
AU - Lee, Hong Kyu
PY - 1987/8/22
Y1 - 1987/8/22
N2 - The epidemiology of insulin dependent diabetes mellitus was evaluated to determine the degree to which the disease results from environmental agents and therefore might be prevented. The results of research indicate that insulin dependent diabetes can be produced in animal models by environmental factors, there are major geographical variations in diabetes, certain populations have shown rapid changes in incidence over time, migrants appear to take on the risk of diabetes in their new country, and certain viruses and chemicals cause insulin. dependent diabetes in humans. The results of genetic and epidemiological studies also show that at least 60% of insulin dependent diabetes world wide, and perhaps over 95%, is environmentally determined and thus potentially avoidable. It is concluded that the primary worldwide determinants of diabetes are environmental not immunogenetic and that identifying and altering the diabetogenic environmental factor(s) are likely to be more effective and less risky in preventing insulin dependent diabetes than current immunogenetic approaches.
AB - The epidemiology of insulin dependent diabetes mellitus was evaluated to determine the degree to which the disease results from environmental agents and therefore might be prevented. The results of research indicate that insulin dependent diabetes can be produced in animal models by environmental factors, there are major geographical variations in diabetes, certain populations have shown rapid changes in incidence over time, migrants appear to take on the risk of diabetes in their new country, and certain viruses and chemicals cause insulin. dependent diabetes in humans. The results of genetic and epidemiological studies also show that at least 60% of insulin dependent diabetes world wide, and perhaps over 95%, is environmentally determined and thus potentially avoidable. It is concluded that the primary worldwide determinants of diabetes are environmental not immunogenetic and that identifying and altering the diabetogenic environmental factor(s) are likely to be more effective and less risky in preventing insulin dependent diabetes than current immunogenetic approaches.
UR - http://www.scopus.com/inward/record.url?scp=0023193767&partnerID=8YFLogxK
U2 - 10.1136/bmj.295.6596.479
DO - 10.1136/bmj.295.6596.479
M3 - Article
C2 - 3117180
AN - SCOPUS:0023193767
SN - 0267-0623
VL - 295
SP - 479
EP - 481
JO - British Medical Journal (Clinical research ed.)
JF - British Medical Journal (Clinical research ed.)
IS - 6596
ER -