Prevalence of insulin resistance in schizophrenia in HUKM

A. R. Fairuz, T. Maniam, B. A.K. Khalid, Fairuz Nazrí Abd Rahman

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This is a cross-sectional study to determine the prevalence of insulin resistance and its associated factors in Hospital UKM patients with schizophrenia using the Homeostatic Model Assessment (HOMA) model. Fasting glucose and insulin from 85 patients were obtained. Fasting glucose revealed 15% of the patients were diabetic, while another 15% had impaired fasting glucose. Using the HOMA model, 68% of the patients had insulin resistance. Univariate analyses found BMI (p<0.001) and waist circumference (p<0.001) to be associated with insulin resistance. The statistical significance disappeared after multivariate analyses. All patients with schizophrenia should be screened and managed as a group at high risk for development of diabetes with emphasis on body weight management.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalMedical Journal of Malaysia
Issue number4
Publication statusPublished - Oct 2007
Externally publishedYes


  • Body weight
  • Diabetes
  • Homeostatic Model Assessment
  • Insulin resistance
  • Schizophrenia
  • Waist circumference

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